CUDC-101

Base Information Edit

Chemical Name:CUDC-101
CAS No.:1012054-59-9
Molecular Formula:C24H26N4O4
Molecular Weight:434.495
Hs Code.:
Mol file:1012054-59-9.mol

Synonyms:7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide;

Suppliers and Price of CUDC-101

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
CUDC 101
10mg
$ 389.00

Usbiological
CUDC 101
5mg
$ 360.00

TRC
CUDC 101
50mg
$ 435.00

Sigma-Aldrich
CUDC 101 A potent inhibitor of HDACs and receptor tyrosine kinases
5mg
$ 158.00

Sigma-Aldrich
CUDC 101 A potent inhibitor of HDACs and receptor tyrosine kinases
25mg
$ 589.00

Matrix Scientific
7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide 95%
100mg
$ 861.00

Matrix Scientific
7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide 95%
1g
$ 1943.00

DC Chemicals
CUDC 101 >98%
1 g
$ 1800.00

DC Chemicals
CUDC 101 >98%
250 mg
$ 900.00

DC Chemicals
CUDC 101 >98%
100 mg
$ 450.00

Total 46 raw suppliers

Chemical Property of CUDC-101 Edit

Chemical Property:

Melting Point:174-177 °C
PKA:9.47±0.20(Predicted)
PSA：109.09000
Density:1.288 g/cm³
LogP:5.11130
Storage Temp.:?20°C
Solubility.:DMSO: soluble

Purity/Quality:

98%,99%, ^*data from raw suppliers

CUDC 101 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description CUDC-101 (1012054-59-9) is a novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inhibits EGFR and HER2,? IC50?= 4.4, 2.4 and 15.7 nM respectively.1?It not only blocks EGFR and HER2 but also attenuates multiple compensatory pathways such as AKT, HER3 and MET which enable tumor cells to escape the effects of conventional EGFR/HER2 inhibitors.1,2
Uses Inhibitor of HDAC, EGFR, and HER2 with an IC50 of 4.4, 2.4, and 15.7 nM, respectively. CUDC-101 is a potent multi-acting HDAC (histone deacetylase), EGFR (epidermal growth factor receptor), and HER2 ( human epidermal growth factor receptor 2) inhibitor for the treatment of cancer.

Technology Process of CUDC-101

There total 17 articles about CUDC-101 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1012057-21-4
ethyl 6-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)heptanoate

: 1012054-59-9
CUDC-101

Guidance literature:: With hydroxylamine; In methanol; at 0 - 25 ℃;
DOI:10.1021/jm901453q

Reference yield: 69.2%

: 1012054-59-9
CUDC-101

Guidance literature:: In tetrahydrofuran; Purification / work up;

Reference yield: 41.0%

: 1012920-21-6
ethyl 6-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)heptanoate

: 1012054-59-9
CUDC-101

Guidance literature:: With potassium hydroxide; hydroxylamine hydrochloride; In methanol; at 0 ℃; for 0.166667h; Product distribution / selectivity;