methyl 3-amino-4-iodobenzoate

Base Information

• Chemical Name: methyl 3-amino-4-iodobenzoate
• CAS No.: 412947-54-7
• Molecular Formula: C8H8INO2
• Molecular Weight: 277.062
• Hs Code.: 2922499990
• Mol file: 412947-54-7.mol

Synonyms:METHYL 3-AMINO-4-IODOBENZOATE;3-amino-4-iodobenzoic acid methyl ester

Chemical Property of methyl 3-amino-4-iodobenzoate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 134-136 °C
• Refractive Index: 1.648
• Boiling Point: 344.269 °C at 760 mmHg
• Flash Point: 162.008 °C
• PSA: 52.32000
• Density: 1.827 g/cm³
• LogP: 2.24120
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Light Sensitive
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl3-Amino-4-iodobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37

MSDS Files:

Useful:

• Uses: Methyl 3-amino-4-iodobenzoate is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.

Technology Process of methyl 3-amino-4-iodobenzoate

There total 5 articles about methyl 3-amino-4-iodobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl ester of 4-iodo-3-nitrobenzoic acid (89976-27-2) → methyl 3-amino-4-iodobenzoate (412947-54-7)

Guidance literature:

With iron; acetic acid; In ethanol; at 65 ℃;

DOI:10.1016/j.tetlet.2007.11.040

Reference yield: 55.0%

4-amino-3-nitrobenzoic acid (1588-83-6) → methyl 3-amino-4-iodobenzoate (412947-54-7)

Guidance literature:

DOI:10.1002/1099-0690(200112)2001:24<4607::AID-EJOC4607>3.0.CO;2-D

Reference yield:

methanol (67-56-1) + 3-amino-4-iodo-benzoic acid (51411-81-5) → methyl 3-amino-4-iodobenzoate (412947-54-7)

Guidance literature:

With thionyl chloride; for 3h; Heating / reflux;

upstream raw materials:

methyl ester of 4-iodo-3-nitrobenzoic acid

4-amino-3-nitrobenzoic acid

4-iodo-3-nitrobenzoic acid

methanol

Downstream raw materials:

(S)-methyl 2-(4-benzyl-2-oxooxazolidin-3-yl)-1H-indole-6-carboxylate

methyl 3-acetamido-4-iodobenzoate

Refernces

• 1、 -. "NOVEL MCH RECEPTOR ANTAGONISTS". Page/Page column 68. . Retrieved 2010/02/11.
• 2、 -. "VIRAL POLYMERASE INHIBITORS". Page 108. . Retrieved 2010/02/07.