8-Chloroquinazoline

Base Information

• Chemical Name: 8-Chloroquinazoline
• CAS No.: 7557-04-2
• Molecular Formula: C8H5ClN2
• Molecular Weight: 164.59
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID10392307
• Nikkaji Number: J101.527C
• Wikidata: Q82190422
• Mol file: 7557-04-2.mol

Synonyms:8-chloroquinazoline;7557-04-2;8-CHLORO-QUINAZOLINE;SCHEMBL10765869;DTXSID10392307;AKOS006274002;AS-76621;CS-0162494;FT-0645683;D94661

Chemical Property of 8-Chloroquinazoline

Chemical Property:

• Vapor Pressure: 0.00624mmHg at 25°C
• Melting Point: 119-120 °C
• Boiling Point: 281°C at 760 mmHg
• PKA: 3.58±0.22(Predicted)
• Flash Point: 150.6°C
• PSA: 25.78000
• Density: 1.349g/cm³
• LogP: 2.28320
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 164.0141259
• Heavy Atom Count: 11
• Complexity: 140

Purity/Quality:

98%min ^*data from raw suppliers

8-Chloroquinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=CN=CN=C2C(=C1)Cl

Technology Process of 8-Chloroquinazoline

There total 1 articles about 8-Chloroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 8-chloro-quinazoline (7557-04-2)

Guidance literature:

DOI:10.1039/jr9620000561

Reference yield: 52.2%

methyl ethynyl ketone (1423-60-5) + α-bromoacetophenone (70-11-1) + 8-chloro-quinazoline (7557-04-2) → 1-(5-Benzoyl-7-chloro-pyrrolo[1,2-c]quinazolin-1-yl)-ethanone

Guidance literature:

With methyloxirane; for 360h; Ambient temperature;

Reference yield: 37.2%

8-chloro-quinazoline (7557-04-2) + 4-chlorobenzoylmethyl bromide (536-38-9) + propynoic acid ethyl ester (623-47-2) → 7-Chloro-5-(4-chloro-benzoyl)-pyrrolo[1,2-c]quinazoline-1-carboxylic acid ethyl ester

Guidance literature:

With methyloxirane; for 360h; Ambient temperature;