2-Amino-3-bromothiophene

Base Information

• Chemical Name: 2-Amino-3-bromothiophene
• CAS No.: 774492-91-0
• Molecular Formula: C₄H₄BrNS
• Molecular Weight: 178.052
• Hs Code.: 2934999090
• Mol file: 774492-91-0.mol

Synonyms:2-thiophenamine, 3-bromo-; 3-Bromothiophen-2-amine

Chemical Property of 2-Amino-3-bromothiophene

Chemical Property:

• Vapor Pressure: 0.05mmHg at 25°C
• Refractive Index: 1.674
• Boiling Point: 235.5 °C at 760 mmHg
• PKA: 0.45±0.10(Predicted)
• Flash Point: 96.2 °C
• PSA: 54.26000
• Density: 1.828 g/cm³
• LogP: 2.67400
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-3-bromothiophene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-3-bromothiophene

There total 2 articles about 2-Amino-3-bromothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.5%

3-bromo-2-(trimethylsilyl)thiophene (77998-62-0) → 3-bromo-2-aminothiophene (774492-91-0)

Guidance literature:

With copper(I) oxide; ammonium hydroxide; In methanol; at 20 ℃; for 24h;

Reference yield: 71.2%

(3-bromothiophen-2-yl)boronic acid (162607-26-3) → 3-bromo-2-aminothiophene (774492-91-0)

Guidance literature:

With copper(I) oxide; ammonium hydroxide; In methanol; at 20 ℃; for 24h; Solvent;

upstream raw materials:

3-bromo-2-(trimethylsilyl)thiophene

(3-bromothiophen-2-yl)boronic acid

Refernces