Technology Process of 12-(Acetyloxy)-3,6,7-trihydroxycholan-24-oic acid methyl ester
There total 8 articles about 12-(Acetyloxy)-3,6,7-trihydroxycholan-24-oic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
zinc(II) tetrahydroborate;
In
diethyl ether; benzene;
for 0.5h;
Ambient temperature;
DOI:10.1016/0039-128X(90)90048-G
- Guidance literature:
-
Multi-step reaction with 6 steps
1: hydrogenchloride / Reflux
2: pyridine / dmap / dichloromethane / 12 h / 20 °C
3: bromine; acetic acid / 48 h / 20 °C
4: potassium hydroxide / methanol / 20 °C
5: toluene-4-sulfonic acid / 20 °C
6: zinc(II) chloride; sodium tetrahydroborate / diethyl ether
With
pyridine; hydrogenchloride; sodium tetrahydroborate; bromine; acetic acid; potassium hydroxide; zinc(II) chloride;
dmap; toluene-4-sulfonic acid;
In
methanol; diethyl ether; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 60 percent / KOH / methanol / Ambient temperature
2: 83 percent / Zn(BH4)2 / benzene; diethyl ether / 0.5 h / Ambient temperature
With
potassium hydroxide; zinc(II) tetrahydroborate;
In
methanol; diethyl ether; benzene;
DOI:10.1016/0039-128X(90)90048-G
