2-BROMO-5-(METHYLTHIO)PYRAZINE

Base Information

• Chemical Name: 2-BROMO-5-(METHYLTHIO)PYRAZINE
• CAS No.: 1049026-49-4
• Molecular Formula: C5H5BrN2S
• Molecular Weight: 205.0756
• Hs Code.: 2933990090
• Mol file: 1049026-49-4.mol

Synonyms:2-BROMO-5-(METHYLTHIO)PYRAZINE;2-BROMO-5-METHYLMERCAPTOPYRAZINE;2-Bromo-5-methylsulfanyl-pyrazine

Chemical Property of 2-BROMO-5-(METHYLTHIO)PYRAZINE

Chemical Property:

• Boiling Point: 270.468 °C at 760 mmHg
• PKA: -2.39±0.10(Predicted)
• Flash Point: 117.375 °C
• PSA: 51.08000
• Density: 1.722 g/cm³
• LogP: 1.96100
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-5-(methylsulfanyl)pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-5-(METHYLTHIO)PYRAZINE

There total 1 articles about 2-BROMO-5-(METHYLTHIO)PYRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-5-dibromopyrazine (23229-26-7) + sodium thiomethoxide (5188-07-8) → 2-bromo-5-(methylsulfanyl)pyrazine (1049026-49-4)

Guidance literature:

In tetrahydrofuran; water; at 0 - 20 ℃; for 1h;

Reference yield: 84.0%

potassium α-benzyloxymethyltrifluoroborate + 2-bromo-5-(methylsulfanyl)pyrazine (1049026-49-4) → 2-((benzyloxy)methyl)-5-(methylthio)pyrazine

Guidance literature:

With dipotassium hydrogenphosphate; (1,2-dimethoxyethane)dichloronickel(II); Ir[dFCF₃ppy]2(bpy)*PF₆; 4,4'-di-tert-butyl-2,2'-bipyridine; In 1,4-dioxane; N,N-dimethyl acetamide; at 24 ℃; for 24h; Irradiation; Inert atmosphere;

DOI:10.1021/acs.orglett.5b01463

Reference yield: 49.0%

2-bromo-5-(methylsulfanyl)pyrazine (1049026-49-4) + potassium 2-phenyl-1-(trifluoroboratomethyl)-1,2-dihydrobenzo[e][1,2]azaborinine → 1-((5-(methylthio)pyrazin-2-yl)methyl)-2-phenyl-1,2-dihydrobenzo[e][1,2]azaborinine

Guidance literature:

With 2,6-dimethylpyridine; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; tetraaqua[4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]nickel(II) chloride; In 1,4-dioxane; at 27 ℃; for 36h; Sealed tube; Inert atmosphere; Irradiation;

DOI:10.1021/acs.orglett.9b00884

upstream raw materials:

2-5-dibromopyrazine

sodium thiomethoxide

Downstream raw materials:

2-bromo-5-(methylsulfonyl)pyrazine

Refernces

• 1、 -. "INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL". Page/Page column 85. . Retrieved 2015/02/25.