7-Chlorofuro[2,3-c]pyridine

Base Information

• Chemical Name: 7-Chlorofuro[2,3-c]pyridine
• CAS No.: 84400-99-7
• Molecular Formula: C7H4ClNO
• Molecular Weight: 153.568
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID50510846
• Nikkaji Number: J848.412K
• Wikidata: Q82369375
• Mol file: 84400-99-7.mol

Synonyms:7-chlorofuro[2,3-c]pyridine;84400-99-7;7-chloro-furo[2,3-c]pyridine;MFCD09834947;Furo[2,3-c]pyridine, 7-chloro-;SCHEMBL658129;DTXSID50510846;YJUYPLVLAHBYCM-UHFFFAOYSA-N;AMY12327;AKOS006327890;PB14748;AS-33795;SY098302;FT-0685063;EN300-116462;J-519215

Chemical Property of 7-Chlorofuro[2,3-c]pyridine

Chemical Property:

• Vapor Pressure: 0.052mmHg at 25°C
• Melting Point: 64-65.5 °C
• Refractive Index: 1.624
• Boiling Point: 242.806 °C at 760 mmHg
• PKA: -0.88±0.30(Predicted)
• Flash Point: 100.646 °C
• PSA: 26.03000
• Density: 1.377 g/cm³
• LogP: 2.48120
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 152.9981414
• Heavy Atom Count: 10
• Complexity: 131

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Chlorofuro[2,3-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C2=C1C=CO2)Cl

Technology Process of 7-Chlorofuro[2,3-c]pyridine

There total 10 articles about 7-Chlorofuro[2,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.6%

furo<2,3-c>pyridin-7(6H)-one (84400-98-6) → 7-Chlorofuro[2,3-c]pyridine (84400-99-7)

Guidance literature:

With trichlorophosphate; for 3h; Heating;

Reference yield: 85.0%

7-chloro-2-trimethylsilylfuro[2,3-c]pyridine (1219102-03-0) → 7-Chlorofuro[2,3-c]pyridine (84400-99-7)

Guidance literature:

7-chloro-2-trimethylsilylfuro[2,3-c]pyridine; With tetrabutyl ammonium fluoride; In tetrahydrofuran; water; at 0 - 20 ℃; for 24h;

With water; In tetrahydrofuran;

DOI:10.1021/jo902666w

Reference yield: 52.0%

furo<2,3-c>pyridine (19539-50-5) → 2,7-dichlorofuro[2,3-c]pyridine (1219102-22-3) + 7-Chlorofuro[2,3-c]pyridine (84400-99-7) + 2-chlorofuro[2,3-c]pyridine

Guidance literature:

furo<2,3-c>pyridine; With n-butyllithium; lithium 2-(dimethylamino)ethanolate; In toluene; at -78 ℃; for 1h;

With hexachloroethane; In tetrahydrofuran; at -78 ℃; for 1h;

With water; regioselective reaction;

DOI:10.1021/jo902666w

upstream raw materials:

furo<2,3-c>pyridin-7(6H)-one

Furo[2,3-c]pyridine 6-oxide

7-chloro-2-trimethylsilylfuro[2,3-c]pyridine

furo<2,3-c>pyridine

Downstream raw materials:

furo<2,3-c>pyridine

acetyl-2 chloro-4 furo<3,2-c>pyridine

2-aminomethylfuro<2,3-c>pyridine

furo<2,3-c>pyridine-2-carboxaldehyde

Refernces

• 1、 Hu, Yun-Jin,St.-Onge, Miguel,Laliberté, Sébastien,Vallée, Frédéric,Jin, Shujuan,Bedard, Leanne,Labrecque, Jean,Albert, Jeffrey S.. "Discovery of a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine and a 1-aryloxyisoquinoline series of TRPA1 antagonists". supporting information. p. 3199 - 3203. Retrieved 2015/02/19.
• 2、 -. "IMIDAZOTHIADIAZOLE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION". . . Retrieved 2013/11/18.