Ethyl 6-(pyrrolidin-1-yl)nicotinate

Base Information

• Chemical Name: Ethyl 6-(pyrrolidin-1-yl)nicotinate
• CAS No.: 897399-74-5
• Molecular Formula: C12H16N2O2
• Molecular Weight: 220.271
• Hs Code.: 2933990090
• Mol file: 897399-74-5.mol

Synonyms:2-(Pyrrolidin-1-yl)pyridine-5-carboxylic acid ethyl ester;6-(Pyrrolidin-1-yl)nicotinic acid ethyl ester;

Chemical Property of Ethyl 6-(pyrrolidin-1-yl)nicotinate

Chemical Property:

• Boiling Point: 362.151 °C at 760 mmHg
• Flash Point: 172.823 °C
• PSA: 42.43000
• Density: 1.15 g/cm³
• LogP: 1.92350
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Ethyl6-(pyrrolidin-1-yl)nicotinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: Ethyl 6-(pyrrolidin-1-yl)nicotinate, a chemical compound, has applications across different fields. In the field of pharmaceuticals and medicinal chemistry, it is often employed as a key intermediate for the synthesis of various pharmaceutical drugs and bioactive compounds, potentially contributing to the development of medications with therapeutic applications. In the realm of organic chemistry, this compound can serve as a versatile building block for the creation of complex organic molecules, supporting research and innovation in chemical synthesis. Additionally, in the field of neuroscience and pharmacology, it may be used as a research tool to investigate the effects of pyrrolidine-containing compounds on neurotransmitter systems and receptors, potentially advancing our understanding of brain function and drug interactions. Its adaptability as a pharmaceutical intermediate, chemical building block, and research tool underscores its significance in advancing drug development, organic chemistry, and scientific understanding in various fields.

Technology Process of Ethyl 6-(pyrrolidin-1-yl)nicotinate

There total 1 articles about Ethyl 6-(pyrrolidin-1-yl)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

pyrrolidine (123-75-1) + 6-chloro-3-pyridinecarboxylic acid ethyl ester (49608-01-7) → 6-pyrrolidin-1-yl-nicotinic acid ethyl ester (897399-74-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃;

Reference yield:

6-pyrrolidin-1-yl-nicotinic acid ethyl ester (897399-74-5) → 6-(pyrrolidine-1-yl)nicotinic acid (210963-95-4)

Guidance literature:

6-pyrrolidin-1-yl-nicotinic acid ethyl ester; With methanol; water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.5h;

With hydrogenchloride; In water;

upstream raw materials:

pyrrolidine

6-chloro-3-pyridinecarboxylic acid ethyl ester

Downstream raw materials:

6-(pyrrolidine-1-yl)nicotinic acid

Refernces