methyl 3-bromo-4-methyl-5-nitropicolinate

Base Information

• Chemical Name: methyl 3-bromo-4-methyl-5-nitropicolinate
• CAS No.: 1150618-07-7
• Molecular Formula: C8H7BrN2O4
• Molecular Weight: 275.06
• Hs Code.: 2933399090
• Mol file: 1150618-07-7.mol

Synonyms:Methyl 3-bromo-4-methyl-5-nitro-pyridine-2-carboxylate;3-Bromo-4-methyl-5-nitro-pyridine-2-carboxylic acid methyl ester;

Chemical Property of methyl 3-bromo-4-methyl-5-nitropicolinate

Chemical Property:

• Boiling Point: 377.186 °C at 760 mmHg
• Flash Point: 181.916 °C
• PSA: 85.01000
• Density: 1.669 g/cm³
• LogP: 2.37050
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Methyl3-bromo-4-methyl-5-nitropicolinate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-bromo-4-methyl-5-nitropicolinate

There total 4 articles about methyl 3-bromo-4-methyl-5-nitropicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + C6H4BrIN2O2 (1150618-06-6) → C8H7BrN2O4 (1150618-07-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In acetonitrile; at 70 ℃; for 16h;

DOI:10.1039/c3md00014a

Reference yield:

3-bromo-2-chloro-4-methyl-5-nitropyridine (1049706-73-1) → C8H7BrN2O4 (1150618-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium iodide; chloro-trimethyl-silane; propiononitrile / 16 h / 20 °C

2: triethylamine; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 16 h / 70 °C

With bis-triphenylphosphine-palladium(II) chloride; chloro-trimethyl-silane; triethylamine; propiononitrile; sodium iodide; In acetonitrile;

DOI:10.1039/c3md00014a

Reference yield:

2-hydroxy-4-methyl-5-nitropyridine (21901-41-7) → C8H7BrN2O4 (1150618-07-7)

Guidance literature:

Multi-step reaction with 4 steps

1: bromine; acetic acid / 3 h / 20 °C

2: trichlorophosphate / acetonitrile / 6 h / 20 °C

3: sodium iodide; chloro-trimethyl-silane; propiononitrile / 16 h / 20 °C

4: triethylamine; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 16 h / 70 °C

With bis-triphenylphosphine-palladium(II) chloride; chloro-trimethyl-silane; bromine; acetic acid; triethylamine; propiononitrile; sodium iodide; trichlorophosphate; In acetonitrile;

DOI:10.1039/c3md00014a

upstream raw materials:

3-bromo-2-chloro-4-methyl-5-nitropyridine

methanol

carbon monoxide

C₆H₄BrIN₂O₂

Refernces