CX-3543

Base Information

• Chemical Name: CX-3543
• CAS No.: 865311-47-3
• Molecular Formula: C₃₅H₃₃FN₆O₃
• Molecular Weight: 604.684
• Mol file: 865311-47-3.mol

Synonyms:5-Fluoro-N-(2-((2S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-(3-(pyrazin-2- yl)pyrrolidin-1-yl)-3H-benzo(b)pyrido(3,2,1-kl)phenoxazine-2-carboxamide;CX 3543;CX-3543;Quarfloxacin;UNII-8M31J5031Q;3H-Benzo(b)pyrido(3,2,1-kl)phenoxazine-2-carboxamide, 5-fluoro-N-(2-((2S)- 1-methyl-2-pyrrolidinyl)ethyl)-3-oxo-6-(3-pyrazinyl-1-pyrrolidinyl)-;

Chemical Property of CX-3543

Chemical Property:

• Boiling Point: 845.3±65.0 °C(Predicted)
• PKA: 11.46±0.20(Predicted)
• PSA: 99.47000
• Density: 1.44
• LogP: 6.06690

Purity/Quality:

99% ^*data from raw suppliers

Quarfloxin(CX-3543) >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CX-3543

There total 3 articles about CX-3543 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

{2-[(2R)-1-methylpyrrolidin-2-yl]ethyl}amine (422545-96-8) + C30H23FN4O4 (876060-50-3) → 5-Fluoro-N-[2-[1-methylpyrrolidin-2(R)-yl]ethyl]-3-oxo-6-[3-(2-pyrazinyl)pyrrolidin-1-yl]-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide (876059-62-0,865311-47-3)

Guidance literature:

With aluminum (III) chloride; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tetlet.2010.12.108

Reference yield:

(S)-2-(1-methylpyrrolidin-2-yl)ethan-1-amine (422545-95-7,422545-96-8) + C30H23FN4O4 (876060-50-3) → quarfloxin (865311-47-3)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

(S)-2-(1-methylpyrrolidin-2-yl)ethan-1-amine (422545-95-7,422545-96-8) + C28H19FN4O4 (876060-51-4) → quarfloxacin (865311-47-3)

Guidance literature:

C₂₈H₁₉FN₄O₄; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 1h;

(S)-2-(1-methylpyrrolidin-2-yl)ethan-1-amine; In 1-methyl-pyrrolidin-2-one; for 0.5h;

upstream raw materials:

(S)-2-(1-methylpyrrolidin-2-yl)ethan-1-amine

C₂₈H₁₉FN₄O₄

C₃₀H₂₃FN₄O₄

{2-[(2R)-1-methylpyrrolidin-2-yl]ethyl}amine

Refernces

• 1、 -. "Novel benzothiazole compounds and methods of use thereof". Page/Page column 13. . Retrieved 2010/10/20.