2-(4-Chlor-phenyl)-capronsaeure

Base Information

• Chemical Name: 2-(4-Chlor-phenyl)-capronsaeure
• CAS No.: 1669-65-4
• Molecular Formula: C₁₂H₁₅ClO₂
• Molecular Weight: 226.703
• Mol file: 1669-65-4.mol

Synonyms:

Chemical Property of 2-(4-Chlor-phenyl)-capronsaeure

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-Chlor-phenyl)-capronsaeure

There total 3 articles about 2-(4-Chlor-phenyl)-capronsaeure which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorophenylacetic Acid (1878-66-6) + 1-iodo-butane (542-69-8) → 2-(4-Chlor-phenyl)-capronsaeure (1669-65-4)

Guidance literature:

4-chlorophenylacetic Acid; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 0 ℃;

1-iodo-butane; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1002/adsc.200800532

Reference yield:

α-Butyl-4-chlorbenzylcyanid (2124-74-5) → 2-(4-Chlor-phenyl)-capronsaeure (1669-65-4)

Guidance literature:

With sodium hydroxide; In ethanol; Heating;

DOI:10.1139/v64-413

Reference yield:

p-chlorobenzyl cyanide (140-53-4) → 2-(4-Chlor-phenyl)-capronsaeure (1669-65-4)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) aq. 2NEt₃>Cl, (ii) NaOMe, PhCHO, MeOH

2: aq. NaOH / ethanol / Heating

With sodium hydroxide; In ethanol;

DOI:10.1139/v64-413

upstream raw materials:

α-Butyl-4-chlorbenzylcyanid

p-chlorobenzyl cyanide

4-chlorophenylacetic Acid

1-iodo-butane

Refernces

• 1、 Lv, Hui,Zhang, Yan-Rong,Huang, Xue-Liang,Ye, Song. "Asymmetric dimerization of disubstituted ketenes catalyzed by N-heterocyclic carbenes". supporting information; experimental part. p. 2715 - 2718. Retrieved 2009/10/20.