6-pyrrolidin-1-yl- pyridineboronic acid

Base Information

• Chemical Name: 6-pyrrolidin-1-yl- pyridineboronic acid
• CAS No.: 1150114-75-2
• Molecular Formula: C9H13BN2O2
• Molecular Weight: 192.025
• Hs Code.: 2933990090
• Mol file: 1150114-75-2.mol

Synonyms:Boronic acid, B-[6-(1-pyrrolidinyl)-3-pyridinyl]-;(6-Pyrrolidin-1-yl-3-pyridyl)boronic acid;2-Pyrrolidin-1-yl-pyridine-5-boronic acid;

Chemical Property of 6-pyrrolidin-1-yl- pyridineboronic acid

Chemical Property:

• Boiling Point: 421.3 °C at 760 mmHg
• PKA: 4.28±0.17(Predicted)
• Flash Point: 208.6 °C
• PSA: 56.59000
• Density: 1.25 g/cm³
• LogP: -0.57340

Purity/Quality:

99% ^*data from raw suppliers

6-Pyrrolidin-1-yl-pyridine-3-boronic acid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-pyrrolidin-1-yl- pyridineboronic acid

There total 2 articles about 6-pyrrolidin-1-yl- pyridineboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

Trimethyl borate (121-43-7,63156-11-6) + 5-bromo-2-(pyrrolidin-1-yl)pyridine (210963-93-2) → (6-(pyrrolidin-1-yl)pyridin-3-yl)boronic acid (1150114-75-2)

Guidance literature:

5-bromo-2-(pyrrolidin-1-yl)pyridine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

Trimethyl borate; In tetrahydrofuran; at 20 ℃;

Reference yield:

→ (6-(pyrrolidin-1-yl)pyridin-3-yl)boronic acid (1150114-75-2)

Guidance literature:

Reference yield: 83.3%

9-bromo-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one + (6-(pyrrolidin-1-yl)pyridin-3-yl)boronic acid (1150114-75-2) → 9-(6-(pyrrolidin-1-yl)pyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; at 80 ℃; for 4h;

DOI:10.1016/j.ejmech.2019.04.048

upstream raw materials:

Trimethyl borate

5-bromo-2-(pyrrolidin-1-yl)pyridine

Downstream raw materials:

N-(5-methyl-1,2-oxazol-3-yl)-2-[1-({3-[6-(pyrrolidin-1-yl)pyridin-3-yl]phenyl}methyl)-1H-indole-3-sulfonyl]acetamide

Refernces

• 1、 -. "SUBSTITUTED PYRIDOPYRAZINES AS NOVEL SYK INHIBITORS". Paragraph 0170; 0171; 0172. . Retrieved 2014/05/08.