2-(4-METHYL-THIAZOL-5-YL)-ETHYLAMINE

Base Information

• Chemical Name: 2-(4-METHYL-THIAZOL-5-YL)-ETHYLAMINE
• CAS No.: 58981-35-4
• Molecular Formula: C6H10N2S
• Molecular Weight: 142.225
• Hs Code.: 2934100090
• Mol file: 58981-35-4.mol

Synonyms:2-(4-Methyl-thiazol-5-yl)-ethylamine;5-Thiazoleethanamine, 4-methyl-;

Chemical Property of 2-(4-METHYL-THIAZOL-5-YL)-ETHYLAMINE

Chemical Property:

• Vapor Pressure: 0.0297mmHg at 25°C
• Refractive Index: 1.564
• Boiling Point: 244.8 °C at 760 mmHg
• Flash Point: 101.9 °C
• PSA: 67.15000
• Density: 1.138 g/cm³
• LogP: 1.65300
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), DMSO (Sparingly), Methanol (Sparingly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(4-Methylthiazol-5-yl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(4-Methylthiazol-5-yl)ethanamine is used in the synthesis and biological testing of several new H2 (Histamine) agonists.

Technology Process of 2-(4-METHYL-THIAZOL-5-YL)-ETHYLAMINE

There total 11 articles about 2-(4-METHYL-THIAZOL-5-YL)-ETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-(2-azidoethyl)-4-methylthiazole (153805-36-8) → VUF 8952 (58981-35-4)

Guidance literature:

With hydrogen; Lindlar's catalyst; In methanol; for 2.5h; under 760 Torr;

DOI:10.1021/jm00028a013

Reference yield: 67.0%

4-methyl-5-vinylthiazole (1759-28-0) → VUF 8952 (58981-35-4)

Guidance literature:

With 3,6‐di‐tert‐butyl‐9‐mesityl‐10‐phenylacridin‐10‐ium tetrafluoroborate; ammonium carbonate; 2-amino-benzenethiol; In dichloromethane; acetonitrile; at 20 ℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1002/anie.202016679

Reference yield:

(4-methyl-1,3-thiazol-5-yl)acetonitrile (50382-33-7) → VUF 8952 (58981-35-4)

Guidance literature:

With ethanol; nickel; under 2206.5 Torr; Hydrogenation;

DOI:10.1021/ja01849a049

upstream raw materials:

(4-methyl-1,3-thiazol-5-yl)acetonitrile

3-(4-methyl-thiazol-5-yl)-propionic acid amide

3-(4-methyl-thiazol-5-yl)-propionic acid ethyl ester

4-methyl-5-(β-phthalimidoethyl)thiazole

Downstream raw materials:

L-idonamide, 6-cyclohexyl-2,5,6-trideoxy-5-amino-2-(1-methylethyl)-N-<2-methyl-1-<<<2-(4-methyl-5-thiazolyl)ethyl>amino>carbonyl>butyl>-, <3aS-<3aα,4β(1R*,2R*),6aα>>-

carbamic acid, <1-<2,2-dimethyl-5-<2-cyclohexyl-1-<<<2-methyl-1-<<(2-pyridinylmethyl)amino>carbonyl>butyl>amino>carbonyl>ethyl>-1,3-dioxolan-4-yl>-2-methylpropyl>-, 1,1-dimethylethyl ester, <4R-<4α(R*),5β(S*)>>

5-hydroxyethyl-4-methylthiazole

Refernces

• 1、 Du, Yi-Dan,Chen, Bi-Hong,Shu, Wei. "Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination". supporting information. p. 9875 - 9880. Retrieved 2021/03/29.