5,6,7,8-Tetrahydronaphthalene-2-carbaldehyde

Base Information

• Chemical Name: 5,6,7,8-Tetrahydronaphthalene-2-carbaldehyde
• CAS No.: 51529-97-6
• Molecular Formula: C11H12O
• Molecular Weight: 160.216
• Hs Code.: 2912299000
• European Community (EC) Number: 673-362-6
• DSSTox Substance ID: DTXSID10375236
• Nikkaji Number: J469.370A
• Wikidata: Q72506238
• Mol file: 51529-97-6.mol

Synonyms:5,6,7,8-tetrahydronaphthalene-2-carbaldehyde;51529-97-6;5,6,7,8-Tetrahydro-naphthalene-2-carbaldehyde;5,6,7,8-Tetrahydronaphthalene-2-carboxaldehyde;1,2,3,4-tetrahydro-6-naphthaldehyde;tetralin-6-carbaldehyde;6-formyltetralin;2-Naphthalenecarboxaldehyde, 5,6,7,8-tetrahydro-;SCHEMBL1525600;DTXSID10375236;NYNSNUNMTUNAEO-UHFFFAOYSA-N;MFCD00017658;AKOS000346316;1.2.3.4- Tetrahydro-6-naphthaldehyd;BS-17439;CS-0136670;FT-0749181;EN300-216265;N12349;Z385369922

Chemical Property of 5,6,7,8-Tetrahydronaphthalene-2-carbaldehyde

Chemical Property:

• Appearance/Colour: light yellow transparent liquid
• Boiling Point: 284.6 ºC at 760 mmHg
• Flash Point: 151.5 ºC
• PSA: 17.07000
• Density: 1.083g/cm³
• LogP: 2.37790
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 160.088815002
• Heavy Atom Count: 12
• Complexity: 164

Purity/Quality:

98%min ^*data from raw suppliers

5,6,7,8-tetrahydronaphthalene-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC2=C(C1)C=CC(=C2)C=O

Technology Process of 5,6,7,8-Tetrahydronaphthalene-2-carbaldehyde

There total 25 articles about 5,6,7,8-Tetrahydronaphthalene-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tetralin (119-64-2) + Dichloromethyl methyl ether (4885-02-3) → 5,6,7,8-tetrahydronaphthalene-2-carbaldehyde (51529-97-6)

Guidance literature:

With tin(IV) chloride; In chloroform; at 0 ℃; for 1h;

DOI:10.1021/jm00075a027

Reference yield: 79.0%

6-hydroxymethyl-1,2,3,4-tetrahydronaphthalene (6883-81-4) → 5,6,7,8-tetrahydronaphthalene-2-carbaldehyde (51529-97-6)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1007/BF00810848

Reference yield: 25.0%

1-allyl-1-cyclohexanol (1123-34-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5,6,7,8-tetrahydronaphthalene-2-carbaldehyde (51529-97-6) + tetralin-5,7-dicarboxaldehyde (121220-73-3)

Guidance literature:

With trichlorophosphate; room temp., 30 min, then boiling water bath, 6h;

upstream raw materials:

tetralin

6-chloromethyl-1,2,3,4-tetrahydronaphthalene

6-hydroxymethyl-1,2,3,4-tetrahydronaphthalene

5,6,7,8-tetrahydro-[2]naphthoic acid anilide

Downstream raw materials:

1,2,3,4-tetrahydro-2-naphthoic acid

6-hydroxymethyl-1,2,3,4-tetrahydronaphthalene

naphthalene

tetralin

Refernces

• 1、 -. "N-substituted acrylamide derivatives as DHODH inhibitors and preparation and use of N-substituted acrylamide derivatives". Paragraph 0233-0234; 0236. . Retrieved 2019/11/04.
• 2、 Barman, Sanmitra,You, Lei,Chen, Ran,Codrea, Vlad,Kago, Grace,Edupuganti, Ramakrishna,Robertus, Jon,Krug, Robert M.,Anslyn, Eric V.. "Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses". . p. 81 - 90. Retrieved 2014/01/06.