4-Fluoro-3-nitroanisole

Base Information

• Chemical Name: 4-Fluoro-3-nitroanisole
• CAS No.: 61324-93-4
• Molecular Formula: C7H6FNO3
• Molecular Weight: 171.128
• Hs Code.: 2909309090
• Mol file: 61324-93-4.mol

Synonyms:4-Fluoro-3-nitrophenyl methyl ether;

Chemical Property of 4-Fluoro-3-nitroanisole

Chemical Property:

• Vapor Pressure: 0.00679mmHg at 25°C
• Refractive Index: 1.521
• Boiling Point: 279.5 °C at 760 mmHg
• Flash Point: 122.8 °C
• PSA: 55.05000
• Density: 1.321 g/cm³
• LogP: 2.26570
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

1-Fluoro-4-methoxy-2-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Fluoro-4-methoxy-2-nitrobenzene is a useful synthetic compound.

Technology Process of 4-Fluoro-3-nitroanisole

There total 2 articles about 4-Fluoro-3-nitroanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.4%

4-fluoro-3-nitrophenol (2105-96-6) + methyl iodide (74-88-4) → 1-fluoro-nitro-4-methoxybenzene (61324-93-4)

Guidance literature:

With potassium carbonate; In acetone; at 50 ℃;

Reference yield:

→ 1-fluoro-nitro-4-methoxybenzene (61324-93-4)

Guidance literature:

Reference yield: 96.0%

α-naphthol (90-15-3) + 1-fluoro-nitro-4-methoxybenzene (61324-93-4) → 1-(4-methoxy-2-nitrophenoxy)naphthalene

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 100 ℃; for 2h; Inert atmosphere;

upstream raw materials:

4-fluoro-3-nitrophenol

methyl iodide

Downstream raw materials:

4-methoxy-2-nitro-1,1'-biphenyl

4-(4-Methoxy-2-nitro-phenylamino)-piperidine-1-carboxylic acid ethyl ester

N-benzyl-4-methoxy-2-nitrobenzenamine

1-(4-methoxy-2-nitrophenyl)piperidine

Refernces

• 1、 -. "TRPML MODULATORS". Paragraph 0549. . Retrieved 2021/06/26.
• 2、 Widdowson, David A.,Wilhelm, Rene. "Palladium catalysed Suzuki reactions of fluoroarenes". . p. 578 - 579. Retrieved 2007/10/03.