1-BOC-3-AMINOPIPERIDINE

Base Information

• Chemical Name: 1-BOC-3-AMINOPIPERIDINE
• CAS No.: 144243-24-3
• Molecular Formula: C10H20N2O2
• Molecular Weight: 200.281
• Hs Code.: 29333990
• Mol file: 144243-24-3.mol

Synonyms:N-BOC-3-Aminopiperidine;

Chemical Property of 1-BOC-3-AMINOPIPERIDINE

Chemical Property:

• Vapor Pressure: 0.00456mmHg at 25°C
• Melting Point: 181-182℃
• Boiling Point: 277.3 °C at 760 mmHg
• Flash Point: 121.5 °C
• PSA: 75.63000
• Density: 1.041 g/cm³
• LogP: 1.51920

Purity/Quality:

98% or more ^*data from raw suppliers

1-Boc-3-aminopiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R22:; R36/37/38:
• Hazard Codes: Xn:Harmful
• Statements: R22:; R36/37/38:
• Safety Statements: S26:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-3-AMINOPIPERIDINE

There total 11 articles about 1-BOC-3-AMINOPIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.5%

3-aminopiperidine (54012-73-6,80918-66-7,127294-73-9,128441-15-6) + di-tert-butyl dicarbonate (24424-99-5) → tert‐butyl 3‐aminopiperidine‐1‐carboxylate (144243-24-3) + t-butyl piperidin-3-ylcarbamate (184637-48-7,172603-05-3)

Guidance literature:

With sodium hydroxide; In ethanol; at 10 - 15 ℃; for 1h; pH=11.8 - 12.2;

Reference yield: 90.0%

3-Azido-1-(tert-butoxycarbonyl)piperidine (129888-61-5) → tert‐butyl 3‐aminopiperidine‐1‐carboxylate (144243-24-3)

Guidance literature:

With 10% palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; for 12h; under 760.051 Torr;

DOI:10.1016/j.tet.2010.12.029

Reference yield: 69.2%

→ tert‐butyl 3‐aminopiperidine‐1‐carboxylate (144243-24-3) + t-butyl piperidin-3-ylcarbamate (184637-48-7,172603-05-3)

Guidance literature:

Product distribution / selectivity;

upstream raw materials:

3-Azido-1-(tert-butoxycarbonyl)piperidine

3-hydroxypiperazine

di-tert-butyl dicarbonate

N-tert-butoxycarbonyl-3-piperidinol

Downstream raw materials:

1-(tert-butoxycarbonyl)-3-(1-pyrrolidinyl)piperidine

(+/-)-N-(1-tert-butoxycarbonyl-3-piperidyl)-3,4-dimethoxy-6-(ethoxycarbonylamino)benzamide

1-(tert-butoxycarbonyl)-3-(phenylamino)piperidine

tert-butyl 3-[(4-methoxyphenyl)amino]piperidine-1-carboxylate

Refernces

• 1、 Kova?ková, Soňa,Dra?ínsky, Martin,Rejman, Dominik. "The synthesis of piperidine nucleoside analogs - A comparison of several methods to access the introduction of nucleobases". experimental part. p. 1485 - 1500. Retrieved 2011/04/15.
• 2、 -. "PROCESS FOR PRODUCING 1-ALKOXYCARBONYL NITROGENOUS SATURATED HETEROCYCLIC DERIVATIVE". Page 7. . Retrieved 2008/06/13.