Technology Process of 4-(4-Fluorophenoxy)phenylboronic acid
There total 8 articles about 4-(4-Fluorophenoxy)phenylboronic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-bromo-4-(4-fluorophenoxy) benzene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
for 0.666667h;
Cooling with ethanol-dry ice;
Triisopropyl borate;
In
tetrahydrofuran; hexane;
- Guidance literature:
-
1-(4-fluorophenoxy)-4-bromobenzene;
With
n-butyllithium;
In
tetrahydrofuran;
at -78 - -65 ℃;
for 1h;
Inert atmosphere;
bis(pinacol)diborane;
In
tetrahydrofuran;
at -60 - 0 ℃;
for 3h;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N,N-dimethylglycine hydrochoride; copper(l) iodide; caesium carbonate / 1,4-dioxane / 48 h / 90 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere
2.2: -78 °C / Inert atmosphere
3.1: hydrogenchloride / water / Inert atmosphere
With
hydrogenchloride; copper(l) iodide; n-butyllithium; N,N-dimethylglycine hydrochoride; caesium carbonate;
In
tetrahydrofuran; 1,4-dioxane; water;
1.1: |Ullmann Condensation;
DOI:10.1039/c6tc01594h
