5-(dimethylamino)-pentanenitrile

Base Information

• Chemical Name: 5-(dimethylamino)-pentanenitrile
• CAS No.: 3209-45-8
• Molecular Formula: C₇H₁₄N₂
• Molecular Weight: 126.202
• Mol file: 3209-45-8.mol

Synonyms:

Chemical Property of 5-(dimethylamino)-pentanenitrile

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

5-(Dimethylamino)pentanenitrilehydrobromide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(dimethylamino)-pentanenitrile

There total 7 articles about 5-(dimethylamino)-pentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-bromopentan-1-nitrile (5414-21-1) + dimethyl amine (124-40-3) → 5-(dimethylamino)-pentanenitrile (3209-45-8)

Guidance literature:

In tetrahydrofuran; water; for 2h; Heating;

DOI:10.1016/S0968-0896(98)00132-1

Reference yield: 79.0%

δ-chlorovaleronitrile (6280-87-1) + dimethyl amine (124-40-3) → 5-(dimethylamino)-pentanenitrile (3209-45-8)

Guidance literature:

With sodium iodide; In water; at 20 ℃; for 16h;

DOI:10.1002/chem.201902917

Reference yield:

5-bromopentan-1-nitrile (5414-21-1) → 5-(dimethylamino)-pentanenitrile (3209-45-8)

Guidance literature:

With sodium iodide; In acetone;

upstream raw materials:

5-dimethylamino-pent-3-enenitrile

5-iodovaleronitrile

dimethyl amine

δ-chlorovaleronitrile

Downstream raw materials:

Bis-<5-dimethylamino-pentyl-(1)>-amin

N,N-dimethyl-1,5-pentanediamine

5-(dimethylamino)pentanoic acid

Refernces

• 1、 Wong, Jeff Y. F.,Tobin, John M.,Vilela, Filipe,Barker, Graeme. "Batch Versus Flow Lithiation–Substitution of 1,3,4-Oxadiazoles: Exploitation of Unstable Intermediates Using Flow Chemistry". supporting information. p. 12439 - 12445. Retrieved 2019/09/06.
• 2、 Sassaman, Mark B.,Giovanelli, John,Sood, Virendar K.,Eckelman, William C.. "Synthesis and screening of conformationally restricted and conformationally free N-(tertiary aminoalkyl)dithiocarbamic acids and esters as inhibitors of neuronal nitric oxide synthase". . p. 1759 - 1766. Retrieved 2007/10/03.