1,3-THIAZOLE-2-BORONIC ACID

Base Information

• Chemical Name: 1,3-THIAZOLE-2-BORONIC ACID
• CAS No.: 389630-95-9
• Molecular Formula: C3H4BNO2S
• Molecular Weight: 128.947
• Hs Code.: 2934100090
• Mol file: 389630-95-9.mol

Synonyms:1,3-Thiazol-2-ylboronic acid;Thiazole-2-boronicacid;Boronic acid, B-2-thiazolyl-;

Chemical Property of 1,3-THIAZOLE-2-BORONIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.565
• Boiling Point: 320.926 °C at 760 mmHg
• PKA: 7.68±0.53(Predicted)
• Flash Point: 147.891 °C
• PSA: 81.59000
• Density: 1.437 g/cm³
• LogP: -1.17710

Purity/Quality:

99% ^*data from raw suppliers

Thiazole-2-boronic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Used as a reactant in the preparation of arylbenzoxazoles as potent and selective receptor-β ligands.

Technology Process of 1,3-THIAZOLE-2-BORONIC ACID

There total 1 articles about 1,3-THIAZOLE-2-BORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-thiazole (288-47-1) + Trimethyl borate (121-43-7,63156-11-6) → (thiazol-2-yl)boronic acid (389630-95-9)

Guidance literature:

With n-butyllithium; In tetrahydrofuran;

Reference yield: 96.0%

methyl 3-(((perfluorophenyl)sulfonyl)oxy)-5-(trifluoromethyl)benzoate + (thiazol-2-yl)boronic acid (389630-95-9) → methyl 3-(thiazol-2-yl)-5-(trifluoromethyl)benzoate

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate monohydrate; In tert-butyl alcohol; at 28 ℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tetlet.2015.07.033

Reference yield: 56.0%

4-bromo-benzaldehyde (1122-91-4) + (thiazol-2-yl)boronic acid (389630-95-9) → 4-(thiazol-2-yl)-benzaldehyde (198904-53-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In dimethyl sulfoxide; at 120 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.ejmech.2020.112147

upstream raw materials:

1,3-thiazole

Trimethyl borate

Downstream raw materials:

{methyl-[2-(3-thiazol-2-ylbiphenyl-4-yloxy)ethyl]-amino}-acetic acid tert-butyl ester

C₂₃H₂₀N₈OS

C₂₀H₁₅N₇S

4-(thiazol-2-yl)-benzaldehyde

Refernces

• 1、 -. "Inhibitors of protein isoprenyl transferases". . . Retrieved 2008/06/13.
• 2、 -. "Inhibitors of protein isoprenyl transferases". . . Retrieved 2008/06/13.