2-Oxa-6-azaspiro[3.3]heptane

Base Information

• Chemical Name: 2-Oxa-6-azaspiro[3.3]heptane
• CAS No.: 174-78-7
• Molecular Formula: C5H9NO
• Molecular Weight: 99.1326
• Hs Code.: 2934999090
• Mol file: 174-78-7.mol

Synonyms:2-Oxa-6-azaspiro[3.3]heptan;2-oxa-6-azaspiro[3.3]heptane;2-oxa-6-azaspiro[3,3]heptanes oxalic acid salt

Chemical Property of 2-Oxa-6-azaspiro[3.3]heptane

Chemical Property:

• Vapor Pressure: 1.85mmHg at 25°C
• Refractive Index: 1.513
• Boiling Point: 165.7 °C at 760 mmHg
• PKA: 9.73±0.20(Predicted)
• Flash Point: 51.2 °C
• PSA: 21.26000
• Density: 1.12 g/cm³
• LogP: -0.06500
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%, ^*data from raw suppliers

2-Oxa-6-azaspiro[3.3]heptane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Oxa-6-azaspiro[3.3]heptane

There total 6 articles about 2-Oxa-6-azaspiro[3.3]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-benzyl-6-oxa-2-azaspiro[3.3]-heptane (46246-91-7) → 2-oxa-6-azaspiro[3.3]heptane (174-78-7)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethanol; at 45 ℃; for 16h; under 3000.3 Torr; Sealed tube; Industrial scale;

DOI:10.1021/acs.oprd.6b00006

Reference yield:

6-(p-toluenesulfonyl)-2-oxa-6-azaspiro[3.3]heptane (13573-28-9) → 2-oxa-6-azaspiro[3.3]heptane (174-78-7)

Guidance literature:

With methanol; magnesium; for 1h; Sonication;

DOI:10.1002/anie.200800450

Reference yield:

2,2-bis(bromomethyl)-3-bromo-propan-1-ol (1522-92-5) → 2-oxa-6-azaspiro[3.3]heptane (174-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 48 h / 25 - 100 °C

2: magnesium / methanol / 3 h / 20 °C / Sonication

With magnesium; potassium hydroxide; In methanol; ethanol;

upstream raw materials:

6-(p-toluenesulfonyl)-2-oxa-6-azaspiro[3.3]heptane

2-benzyl-6-oxa-2-azaspiro[3.3]-heptane

2,2-bis(bromomethyl)-3-bromo-propan-1-ol

3,3-bis(chloromethyl)oxetane

Downstream raw materials:

bis(2-oxa-6-azaspiro[3.3]heptan-6-ium) ethanedioate

Refernces

• 1、 Van Der Haas, Richard N. S.,Dekker, Jeroen A.,Hassfeld, Jorma,Hager, Anastasia,Fey, Peter,Rubenbauer, Philipp,Damen, Eric. "Synthesis and Properties of 2-Oxa-6-azaspiro[3.3]heptane Sulfonate Salts". . p. 2394 - 2401. Retrieved 2017/05/22.
• 2、 -. "PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF". Page/Page column 69. . Retrieved 2014/01/17.