3-Methoxy-2-cyclopenten-1-one

Base Information

• Chemical Name: 3-Methoxy-2-cyclopenten-1-one
• CAS No.: 4683-50-5
• Molecular Formula: C6H8O2
• Molecular Weight: 112.128
• Hs Code.: 2914509090
• Mol file: 4683-50-5.mol

Synonyms:2-cyclopenten-1-one, 3-methoxy-;

Chemical Property of 3-Methoxy-2-cyclopenten-1-one

Chemical Property:

• Vapor Pressure: 0.152mmHg at 25°C
• Melting Point: 49-53 °C(lit.)
• Refractive Index: 1.466
• Boiling Point: 214.9 °C at 760 mmHg
• Flash Point: 96.5 °C
• PSA: 26.30000
• Density: 1.06 g/cm³
• LogP: 0.87960
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Methoxycyclopent-2-enone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 3-Methoxy-2-cyclopenten-1-one (3-methoxycyclopent-2-enone) may be used in the following studies:Synthesis of 3-cyclopentyl-2-cyclopenten-1-one.As a starting material in the synthesis of 3-alkyl-2-aryl-2-cyclopenten-1-one oxime derivatives and kjellmanianone, an antibiotic.As one of the reagent in the synthesis of 3-aryl enones.Preparation of 1:1 diastereomeric mixture of TBS (tert-butyldimethylsilyl)-protected enones.

Technology Process of 3-Methoxy-2-cyclopenten-1-one

There total 12 articles about 3-Methoxy-2-cyclopenten-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 1,3-cyclopentadione (3859-41-4) → 3-methoxycyclopent-2-enone (4683-50-5)

Guidance literature:

With iodine; at 23 ℃; for 48h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b00841

Reference yield: 94.0%

1,3-cyclopentadione (3859-41-4) + dimethyl sulfate (77-78-1) → 3-methoxycyclopent-2-enone (4683-50-5)

Guidance literature:

With potassium carbonate; In acetone; at 20 - 60 ℃; for 8h;

DOI:10.1021/jo801911s

Reference yield: 80.0%

methanol (67-56-1) + 3-chlorocyclopent-2-en-1-one (53102-14-0) → 3-methoxycyclopent-2-enone (4683-50-5)

Guidance literature:

With potassium carbonate; for 1h; Ambient temperature;

DOI:10.1021/jo00130a024

upstream raw materials:

diazomethane

1,3-cyclopentadione

methyl iodide

methanol

Downstream raw materials:

methyl (+/-)-4-methoxy-2-oxo-3-cyclopentene-1-carboxylate

4-(3-oxocyclopent-1-enyl)-benzonitrile

3-(3-hydroxycyclopent-1-enyl)benzonitrile

3-[3-(2-pyrrolidin-1-yl-ethylamino)-cyclopent-1-enyl]-benzonitrile

Refernces

• 1、 Kats-Kagan, Roman,Herzon, Seth B.. "The discovery of a novel route to highly substituted -tropolones enables expedient entry to the core of the gukulenins". supporting information. p. 2030 - 2033. Retrieved 2015/04/27.
• 2、 -. "ANTI-VIRAL COMPOUNDS". Page/Page column 181. . Retrieved 2012/06/30.