N,3-dimethylbutan-1-amine hydrochloride

Base Information

• Chemical Name: N,3-dimethylbutan-1-amine hydrochloride
• CAS No.: 2419-59-2
• Molecular Formula: C6H15N^.HCl
• Molecular Weight: 137.653
• Hs Code.: 2921199090
• Mol file: 2419-59-2.mol

Synonyms:N,3-dimethylbutan-1-amine hydrochloride;

Chemical Property of N,3-dimethylbutan-1-amine hydrochloride

Chemical Property:

• Boiling Point: 150.4 °C at 760 mmHg
• Flash Point: 44.7 °C
• PSA: 12.03000
• LogP: 2.44480

Purity/Quality:

99%, ^*data from raw suppliers

N-MethylisoamylamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Methylisoamylamine is a reagent used in the synthesis of hepatitis C polymerase inhibitors.

Technology Process of N,3-dimethylbutan-1-amine hydrochloride

There total 2 articles about N,3-dimethylbutan-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzyl-isopentyl-methyl-amine (134895-08-2) → methyl(3-methylbutyl)amine hydrochloride (2419-59-2)

Guidance literature:

With dichloromethane; hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 24h; atmospheric pressure;

DOI:10.1021/jo0480444

Reference yield:

→ methyl(3-methylbutyl)amine hydrochloride (2419-59-2)

Guidance literature:

Reference yield: 14.3%

5-{1-fluoro-3-[(2-methoxyethoxy)methoxy]-7-oxo-5,6,7,8-tetrahydronaphthalen-2-yl}-1λ6,2,5-thiadiazolidine-1,1,3-trione triethylamine salt + methyl(3-methylbutyl)amine hydrochloride (2419-59-2) → 5-{1-fluoro-3-hydroxy-7-[methyl(3-methylbutyl)amino]-5,6,7,8-tetrahydronaphthalen-2-yl}-1λ6,2,5-thiadiazolidine-1,1,3-trione

Guidance literature:

5-{1-fluoro-3-[(2-methoxyethoxy)methoxy]-7-oxo-5,6,7,8-tetrahydronaphthalen-2-yl}-1λ⁶,2,5-thiadiazolidine-1,1,3-trione triethylamine salt; methyl(3-methylbutyl)amine hydrochloride; With sodium cyanoborohydride; In acetonitrile; at 20 ℃; for 3h;

With hydrogenchloride; In 1,4-dioxane; water; acetonitrile; for 1.5h;

upstream raw materials:

benzyl-isopentyl-methyl-amine

Refernces

• 1、 Wang, Xinyan,Dong, Yanmei,Sun, Jianwei,Xu, Xuenong,Li, Rui,Hu, Yuefei. "Nonracemic betti base as a new chiral auxiliary: Application to total syntheses of enantiopure (2S,6R)-dihydropinidine and (2S,6R)-isosolenopsins". . p. 1897 - 1900. Retrieved 2007/10/03.