Chloromethyl octyl ether

Base Information

• Chemical Name: Chloromethyl octyl ether
• CAS No.: 24566-90-3
• Molecular Formula: C9H19ClO
• Molecular Weight: 178.702
• Hs Code.: 2909199090
• Mol file: 24566-90-3.mol

Synonyms:1-(Chloromethoxy)octane;octane, 1-(chloromethoxy)-;

Chemical Property of Chloromethyl octyl ether

Chemical Property:

• Vapor Pressure: 0.247mmHg at 25°C
• Refractive Index: n20/D 1.437(lit.)
• Boiling Point: 212.8 °C at 760 mmHg
• Flash Point: 88.9 °C
• PSA: 9.23000
• Density: 0.917g/cm³
• LogP: 3.55980
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Chloromethyl octyl ether 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-40
• Safety Statements: 23-26-28-36/37/39-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Chloromethyl octyl ether has been employed as chloromethylation reagent:in chloromethylation of calix[4]arene, methyl ethers of calix[6]arene and calix[8]arenein the synthesis of chloromethylated poly(phthalazinone ether sulfone ketone)in chloromethylation of polyetherethersulphone-polyethersulphone copolymersfor polymers

Technology Process of Chloromethyl octyl ether

There total 6 articles about Chloromethyl octyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + octanol (111-87-5) → octyl chloromethyl ether (24566-90-3)

Guidance literature:

With hydrogenchloride;

DOI:10.1016/j.molliq.2020.112669

Reference yield:

2-(octyloxy)acetic acid (63632-58-6) → octyl chloromethyl ether (24566-90-3)

Guidance literature:

With thionyl chloride; for 3h; Reflux;

Reference yield:

octanol (111-87-5) → octyl chloromethyl ether (24566-90-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / 63 h / 70 °C

2: hydrogenchloride / ethyl acetate; water / 1 h / 20 °C

3: thionyl chloride / 3 h / Reflux

With hydrogenchloride; thionyl chloride; sodium hydroxide; In water; ethyl acetate;

upstream raw materials:

formaldehyd

octanol

2-(octyloxy)acetic acid

Downstream raw materials:

1-Octyloxymethoxy-1-phenyl-propan

(1-Propyl-cyclohexyl)-(octyloxy-methyl)-ether

<1-Aethyl-cyclohexyl>--aether

o-Nitro-phenyl-β-octyloxy-methoxyethylether

Refernces

• 1、 Chor??ewski, Miros?aw,Feder-Kubis, Joanna,Korotkovskii, Vadim I.,Melent'ev, Vyacheslav V.,Pilarz, Jeremiasz,Polishuk, Ilya,Postnikov, Eugene B.,Radchenko, Anton K.,Ryshkova, Olga S.. "Speeds of sound in ionic liquids under elevated pressures. New experimental data and CP-PC-SAFT modelling". . . Retrieved 2020.
• 2、 Vo, Cam-Van T.,Mitchell, T. Andrew,Bode, Jeffrey W.. "Expanded substrate scope and improved reactivity of ether-forming cross-coupling reactions of organotrifluoroborates and acetals". supporting information; experimental part. p. 14082 - 14089. Retrieved 2011/10/12.