ASISCHEM A93504

Base Information

• Chemical Name: ASISCHEM A93504
• CAS No.: 482308-06-5
• Molecular Formula: C11H16N2O2
• Molecular Weight: 208.26
• Mol file: 482308-06-5.mol

Synonyms:Benzenamine, 3-methoxy-4-(4-morpholinyl)-;

Chemical Property of ASISCHEM A93504

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.573
• Boiling Point: 411.054 °C at 760 mmHg
• PKA: 7.56±0.40(Predicted)
• Flash Point: 202.398 °C
• PSA: 47.72000
• Density: 1.163 g/cm³
• LogP: 1.76020

Purity/Quality:

98%min ^*data from raw suppliers

(3-methoxy-4-morpholin-4-ylphenyl)amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ASISCHEM A93504

There total 4 articles about ASISCHEM A93504 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-(2-methoxy-4-nitrophenyl)morpholine (97459-72-8) → 3-methoxy-4-morpholin-4-yl-phenylamine (482308-06-5)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 85 ℃; for 3h;

Reference yield:

1-bromo-2-methoxy-4-nitrobenzene (77337-82-7) → 3-methoxy-4-morpholin-4-yl-phenylamine (482308-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 3 h / 80 °C

2: palladium on carbon; hydrogen / ethanol / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on carbon; hydrogen; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In ethanol; toluene;

DOI:10.1016/j.bmcl.2011.02.075

Reference yield:

1-fluoro-2-methoxy-4-nitrobenzene (454-16-0) → 3-methoxy-4-morpholin-4-yl-phenylamine (482308-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

2: hydrogen; palladium on activated charcoal / ethanol / 5 h / 20 °C / 2585.81 Torr

With palladium on activated charcoal; hydrogen; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

4-(2-methoxy-4-nitrophenyl)morpholine

1-bromo-2-methoxy-4-nitrobenzene

1-fluoro-2-methoxy-4-nitrobenzene

Downstream raw materials:

C₂₄H₂₄N₆O₂

C₂₆H₃₃N₅O₅

(±)-3-bromo-1-(3-methoxy-4-morpholinophenyl)pyrrolidin-2-one

Refernces

• 1、 -. "QUINOLINE AND QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF". Paragraph 00338-00339. . Retrieved 2020/10/09.
• 2、 -. "PYRROLONE OR PYRROLIDINONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS". Paragraph 00207. . Retrieved 2014/03/26.