2-BROMO-6-FLUOROBENZOYL CHLORIDE

Base Information

• Chemical Name: 2-BROMO-6-FLUOROBENZOYL CHLORIDE
• CAS No.: 1020718-20-0
• Molecular Formula: C7H3BrClFO
• Molecular Weight: 237.456
• Hs Code.: 2916399090
• Mol file: 1020718-20-0.mol

Synonyms:2-BROMO-6-FLUOROBENZOYL CHLORIDE

Chemical Property of 2-BROMO-6-FLUOROBENZOYL CHLORIDE

Chemical Property:

• Boiling Point: 235.9 °C at 760 mmHg
• Flash Point: 96.5 °C
• PSA: 17.07000
• Density: 1.742 g/cm³
• LogP: 2.96720
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-6-fluorobenzoyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-6-FLUOROBENZOYL CHLORIDE

There total 1 articles about 2-BROMO-6-FLUOROBENZOYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-6-fluorobenzoic acid (2252-37-1) → 2-bromo-6-(fluoro)benzoyl chloride (1020718-20-0)

Guidance literature:

With thionyl chloride; for 2h; Reflux;

DOI:10.1016/j.cclet.2013.04.047

Reference yield: 98.0%

2-bromo-6-(fluoro)benzoyl chloride (1020718-20-0) + C11H18O3Si (1532528-54-3) → C18H20BrFO4Si (1532528-68-9)

Guidance literature:

C₁₁H₁₈O₃Si; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 25 ℃;

2-bromo-6-(fluoro)benzoyl chloride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 - 25 ℃;

DOI:10.1055/s-0033-1339881

Reference yield: 83.0%

2-bromo-6-(fluoro)benzoyl chloride (1020718-20-0) + 3-amino-4-(benzyloxy)benzaldehyde → N-(2-(benzyloxy)-5-formylphenyl)-2-bromo-6-fluorobenzamide

Guidance literature:

With pyridine; dmap; In pyridine; at 20 ℃;

DOI:10.1016/j.bmcl.2018.03.071

upstream raw materials:

2-bromo-6-fluorobenzoic acid

Downstream raw materials:

ethyl (2-bromo-6-fluorophenyl)acetate

N-benzyl-6-bromo-2-fluoro-N-(2-hydroxyethyl)benzamide

2-(benzylthio)-6-(2-bromo-6-(2-bromo-6-fluorobenzamido)benzamido)-N-methylbenzamide

C₁₈H₂₀BrFO₄Si

Refernces

• 1、 Zhang, Zheng,You, Zhenyuan,Dobrowsky, Rick T.,Blagg, Brian S.J.. "Synthesis and evaluation of a ring-constrained Hsp90 C-terminal inhibitor that exhibits neuroprotective activity". . p. 2701 - 2704. Retrieved 2018.
• 2、 Chen, Li-Yuan,Chuang, Ta-Hsien,Lai, Chin-Hung,Tang, Rong-Shiow. "Palladium-Catalyzed Stereoselective Aza-Wacker-Heck Cyclization: One-Pot Stepwise Strategy toward Tetracyclic Fused Heterocycles". supporting information. p. 9337 - 9341. Retrieved 2020/12/21.
• 3、 Mayer, Camilla,Ladd, Carolyn L.,Charette, André B.. "Utilization of BozPhos as an Effective Ligand in Enantioselective C-H Functionalization of Cyclopropanes: Synthesis of Dihydroisoquinolones and Dihydroquinolones". supporting information. p. 2639 - 2644. Retrieved 2019/04/17.