4-chloro-6-methoxyquinolin-7-ol

Base Information

• Chemical Name: 4-chloro-6-methoxyquinolin-7-ol
• CAS No.: 205448-31-3
• Molecular Formula: C10H8ClNO2
• Molecular Weight: 209.632
• Hs Code.: 2933499090
• Mol file: 205448-31-3.mol

Synonyms:4-Chloro-7-hydroxy-6-methoxyquinoline;4-Chloro-6-methoxyquinolin-7-ol;

Chemical Property of 4-chloro-6-methoxyquinolin-7-ol

Chemical Property:

• Boiling Point: 353.279 °C at 760 mmHg
• PKA: 8.41±0.40(Predicted)
• Flash Point: 167.457 °C
• PSA: 42.35000
• Density: 1.387 g/cm³
• LogP: 2.60240
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%, ^*data from raw suppliers

4-Chloro-6-methoxyquinolin-7-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chloro-6-methoxyquinolin-7-ol

There total 12 articles about 4-chloro-6-methoxyquinolin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

7-(benzyloxy)-4-chloro-6-methoxyquinoline (286371-49-1) → 4-chloro-6-methoxy-7-hydroxyquinoline (205448-31-3)

Guidance literature:

With methanesulfonic acid; trifluoroacetic acid; for 3h; Reflux; Inert atmosphere;

DOI:10.1021/jm8006189

Reference yield: 98.0%

7-benzyloxy-4-chloro-6-methoxyquinoline hydrochloride (205448-30-2) → 4-chloro-6-methoxy-7-hydroxyquinoline (205448-31-3)

Guidance literature:

7-benzyloxy-4-chloro-6-methoxyquinoline hydrochloride; With trifluoroacetic acid; for 5.5h; Heating / reflux;

With sodium hydrogencarbonate; In water;

Reference yield: 75.0%

7-(benzyloxy)-4-chloro-6-methoxyquinoline (286371-49-1) + methyl-phenyl-thioether (100-68-5) → 4-chloro-6-methoxy-7-hydroxyquinoline (205448-31-3)

Guidance literature:

With sodium hydroxide; methanesulfonic acid; In hexane; trifluorormethanesulfonic acid;

upstream raw materials:

7-benzyloxy-4-chloro-6-methoxyquinoline hydrochloride

7-(benzyloxy)-4-chloro-6-methoxyquinoline

methyl-phenyl-thioether

4-benzyloxy-3-methoxyacetophenone

Downstream raw materials:

4-chloro-7-(3-chloropropoxy)-6-methoxyquinoline

C₂₆H₃₀ClN₃O₄

C₂₄H₂₀FN₃O₄

C₃₀H₂₉ClFN₃O₆

Refernces

• 1、 -. "Naphthyridine compound and pharmaceutical composition as well as applications thereof". Paragraph 0080; 0081; 0092; 0093. . Retrieved 2017/08/02.
• 2、 D'Angelo, Noel D.,Bellon, Steven F.,Booker, Shon K.,Cheng, Yuan,Coxon, Angela,Dominguez, Celia,Fellows, Ingrid,Hoffman, Douglas,Hungate, Randall,Kaplan-Lefko, Paula,Lee, Matthew R.,Li, Chun,Liu, Longbin,Rainbeau, Elizabeth,Reider, Paul J.,Rex, Karen,Siegmund, Aaron,Sun, Yaxiong,Tasker, Andrew S.,Xi, Ning,Xu, Shimin,Yang, Yajing,Zhang, Yihong,Burgess, Teresa L.,Dussault, Isabelle,Kim, Tae-Seong. "Design, synthesis, and biological evaluation of potent c-Met inhibitors". experimental part. p. 5766 - 5779. Retrieved 2009/07/25.