2-(4-Bromophenyl)-N-methoxy-N-methylacetamide

Base Information

• Chemical Name: 2-(4-Bromophenyl)-N-methoxy-N-methylacetamide
• CAS No.: 149652-50-6
• Molecular Formula: C10H12BrNO2
• Molecular Weight: 258.115
• Mol file: 149652-50-6.mol

Synonyms:2-(4-BROMOPHENYL)-N-METHOXY-N-METHYLACETAMIDE

Chemical Property of 2-(4-Bromophenyl)-N-methoxy-N-methylacetamide

Chemical Property:

• Boiling Point: 312.4 °C at 760 mmHg
• Flash Point: 142.7 °C
• PSA: 29.54000
• Density: 1.416 g/cm³
• LogP: 2.01140

Purity/Quality:

99.3% ^*data from raw suppliers

2-(4-bromophenyl)-N-methoxy-N-methylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-Bromophenyl)-N-methoxy-N-methylacetamide

There total 4 articles about 2-(4-Bromophenyl)-N-methoxy-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 2-(4-bromophenyl)-acetic acid (1878-68-8) → 2-(4-bromophenyl)-N-methoxy-N-methylacetamide (149652-50-6)

Guidance literature:

2-(4-bromophenyl)-acetic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 1h;

N,O-dimethylhydroxylamine*hydrochloride; With trimethylamine; In tetrahydrofuran; acetonitrile; for 20h;

DOI:10.1134/S1070428017020051

Reference yield: 92.0%

1-((N,O-dimethylhydroxylamino)carbonyl)-1H-imidazole + 2-(4-bromophenyl)-acetic acid (1878-68-8) → 2-(4-bromophenyl)-N-methoxy-N-methylacetamide (149652-50-6)

Guidance literature:

In acetonitrile; at 80 ℃; for 24h; chemoselective reaction; Inert atmosphere; Sealed vial;

DOI:10.1016/j.tet.2011.09.057

Reference yield:

2-(4-bromophenyl)acetyl chloride (37859-24-8) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 2-(4-bromophenyl)-N-methoxy-N-methylacetamide (149652-50-6)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02268

upstream raw materials:

2-(4-bromophenyl)-acetic acid

2-(4-bromophenyl)acetyl chloride

N,O-dimethylhydroxylamine*hydrochloride

Refernces

• 1、 -. "ANTIMICROBIAL COMPOUNDS AND METHODS". Paragraph 00448; 00659. . Retrieved 2020/07/31.
• 2、 Gong, Jun,Li, Shi-Wu,Qurban, Saira,Kang, Qiang. "Enantioselective Mannich Reaction Employing 1,3,5-Triaryl-1,3,5-triazinanes Catalyzed by Chiral-at-Metal Rhodium Complexes". supporting information. p. 3584 - 3593. Retrieved 2017/07/22.