Cholan-24-oic acid, 3,7,12-trihydroxy-, monosodium salt, (3alpha,5beta,7alpha,12alpha)-

Base Information

• Chemical Name: Cholan-24-oic acid, 3,7,12-trihydroxy-, monosodium salt, (3alpha,5beta,7alpha,12alpha)-
• CAS No.: 361-09-1
• Molecular Formula: C24H39NaO5
• Molecular Weight: 430.56
• Hs Code.: 29173990
• Mol file: 361-09-1.mol

Synonyms:Cholan-24-oic acid, 3,7,12-trihydroxy-, monosodium salt, (3.alpha.,5.beta.,7.alpha.,12.alpha.)-;AKOS015894284;AS-56555;FT-0632038;FT-0777777;D95383

Chemical Property of Cholan-24-oic acid, 3,7,12-trihydroxy-, monosodium salt, (3alpha,5beta,7alpha,12alpha)-

Chemical Property:

• Appearance/Colour: white to off-white powder
• Vapor Pressure: 4.59E-16mmHg at 25°C
• Melting Point: 198oC
• Refractive Index: 35 ° (C=0.6, EtOH)
• Boiling Point: 583.9 °C at 760 mmHg
• Flash Point: 321 °C
• PSA: 100.82000
• Density: 0.999 at 20.09℃
• LogP: 2.11400
• Storage Temp.: +15C to +30C
• Solubility.: DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly), Water
• Water Solubility.: 150 g/L (20 ºC)
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 430.26951862
• Heavy Atom Count: 30
• Complexity: 643

Purity/Quality:

99% ^*data from raw suppliers

Sodium Cholate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-36-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CCC(=O)[O-])C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C.[Na+]
• Uses: Sodium cholate is a non-denaturing detergent used for membrane protein extraction.

Technology Process of Cholan-24-oic acid, 3,7,12-trihydroxy-, monosodium salt, (3alpha,5beta,7alpha,12alpha)-

There total 2 articles about Cholan-24-oic acid, 3,7,12-trihydroxy-, monosodium salt, (3alpha,5beta,7alpha,12alpha)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cholic acid (81-25-4) → sodium cholate (361-09-1)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃; for 1h;

DOI:10.1016/j.ejmech.2012.03.020

Reference yield:

→ sodium cholate (361-09-1)

Guidance literature:

Reference yield: 98.0%

sodium cholate (361-09-1) → 3α,7α-dihydroxy-12-oxo-5β-cholan-24-oic acid (2458-08-4)

Guidance literature:

With ethylenediaminetetraacetic acid; Acinetobacter calcoaceticus lwoffii 12α-hydroxysteroid dehydrogenase; sodium pyruvate; NAD; 2-hydroxyethanethiol; lactate dehydrogenase; In aq. phosphate buffer; at 22 ℃; pH=8.5; Enzymatic reaction;

DOI:10.1016/j.steroids.2008.06.013

upstream raw materials:

cholic acid

Downstream raw materials:

7-ketodeoxycholic acid

7,12-dioxolitocholic acid

dehydrocholic acid

3α,7α-dihydroxy-12-oxo-5β-cholan-24-oic acid

Refernces

• 1、 -. "Method for virus inactivation in the presence of polyalkylene glycol as well as the pharmaceutical preparation obtained therewith". . . Retrieved 2008/06/13.