4-bromo-N-(pyridin-3-ylmethyl)aniline

Base Information

• Chemical Name: 4-bromo-N-(pyridin-3-ylmethyl)aniline
• CAS No.: 84324-68-5
• Molecular Formula: C12H11BrN2
• Molecular Weight: 263.137
• Hs Code.: 2933399090
• Mol file: 84324-68-5.mol

Synonyms:3-Pyridinemethanamine, N-(4-bromophenyl)-;

Chemical Property of 4-bromo-N-(pyridin-3-ylmethyl)aniline

Chemical Property:

• Vapor Pressure: 5.45E-06mmHg at 25°C
• Boiling Point: 380.4 °C at 760 mmHg
• Flash Point: 183.9 °C
• PSA: 24.92000
• Density: 1.47 g/cm³
• LogP: 3.52920
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromo-N-(pyridin-3-ylmethyl)aniline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-bromo-N-(pyridin-3-ylmethyl)aniline

There total 2 articles about 4-bromo-N-(pyridin-3-ylmethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.8%

3-pyridinecarboxaldehyde (500-22-1) + 4-bromo-aniline (106-40-1) → (4-bromophenyl)pyridin-3-ylmethylamine (84324-68-5)

Guidance literature:

3-pyridinecarboxaldehyde; 4-bromo-aniline; With methanol; at 85 ℃; for 3h;

With sodium tetrahydroborate; at 0 - 20 ℃; for 19.5h;

Reference yield: 89.0%

3-pyridinecarboxaldehyde (500-22-1) + para-nitrophenyl bromide (586-78-7) → (4-bromophenyl)pyridin-3-ylmethylamine (84324-68-5)

Guidance literature:

With hydrogen; In tert-butyl alcohol; at 120 ℃; for 24h; under 30003 Torr;

DOI:10.1126/science.aan6245

Reference yield: 79.0%

2-methoxy-phenol (90-05-1) + (4-bromophenyl)pyridin-3-ylmethylamine (84324-68-5) → N-[4-(2-methoxyphenoxy)phenyl]pyridin-3-ylmethylamine (353235-63-9)

Guidance literature:

With potassium carbonate; copper(II) oxide; In pyridine; for 44h; Heating;

DOI:10.1021/jm034015u

upstream raw materials:

3-pyridinecarboxaldehyde

4-bromo-aniline

para-nitrophenyl bromide

Downstream raw materials:

N-[4-(2-methoxyphenoxy)phenyl]pyridin-3-ylmethylamine

Refernces

• 1、 -. "RESORCINOL N-ARYL AMIDE COMPOUNDS, FOR USE AS PYRUVATE DEHYDROGENASE KINASE INHIBITORS". Page/Page column 65. . Retrieved 2015/04/15.
• 2、 Johnson, Michael P.,Baez, Melvyn,Jagdmann Jr., G. Erik,Britton, Thomas C.,Large, Thomas H.,Callagaro, David O.,Tizzano, Joseph P.,Monn, James A.,Schoepp, Darryle D.. "Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: Synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2-trifluoroethylsulfonyl)pyrid-3- ylmethylamine". . p. 3189 - 3192. Retrieved 2007/10/03.