(+)-3β-Acetoxy-Δ⁵-aetiensaeure-trans-2-tert.-butyl-cyclohexanolester

Base Information

• Chemical Name: (+)-3β-Acetoxy-Δ⁵-aetiensaeure-trans-2-tert.-butyl-cyclohexanolester
• CAS No.: 557088-93-4
• Molecular Formula: C₃₂H₅₀O₄
• Molecular Weight: 498.747
• Mol file: 557088-93-4.mol

Synonyms:

Chemical Property of (+)-3β-Acetoxy-Δ⁵-aetiensaeure-trans-2-tert.-butyl-cyclohexanolester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-3β-Acetoxy-Δ⁵-aetiensaeure-trans-2-tert.-butyl-cyclohexanolester

There total 2 articles about (+)-3β-Acetoxy-Δ⁵-aetiensaeure-trans-2-tert.-butyl-cyclohexanolester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3β-acetoxyetienic acid (7150-18-7) + trans-2-tert-butylcyclohexan-1-ol (5448-22-6) → trans 2-tert-butylcyclohexanol (98104-30-4) + (+)-(1S,2R)-2-(tert-butyl)cyclohexanol (13492-07-4) + (+)-3β-Acetoxy-Δ5-aetiensaeure-trans-2-tert.-butyl-cyclohexanolester (557088-93-4) + trans-2-t-Butylcyclohexyl-3β-acetoxy-Δ5-aetien-saeureester

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h; Resolution of racemate;

DOI:10.1021/op0200928

Reference yield:

3β-acetoxyetienic acid (7150-18-7) + trans-2-tert-butylcyclohexan-1-ol (5448-22-6) → (+)-3β-Acetoxy-Δ5-aetiensaeure-trans-2-tert.-butyl-cyclohexanolester (557088-93-4)

Guidance literature:

Multistep reaction; (i) oxalyl dichloride, (ii) /BRN= 3194240/, Py;

DOI:10.1021/ja01055a019

Reference yield:

(+)-3β-Acetoxy-Δ5-aetiensaeure-trans-2-tert.-butyl-cyclohexanolester (557088-93-4) → (-)-2-tert-butylcyclohexanone (14132-21-9)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄

2: CrO₃, H₂SO₄

With chromium(VI) oxide; lithium aluminium tetrahydride; sulfuric acid;

DOI:10.1021/ja01476a036

upstream raw materials:

3β-acetoxyetienic acid

trans-2-tert-butylcyclohexan-1-ol

Downstream raw materials:

trans 2-tert-butylcyclohexanol

(-)-2-tert-butylcyclohexanone

Refernces