5-BROMO-4-CHLORO-2-PICOLINE

Base Information

• Chemical Name: 5-BROMO-4-CHLORO-2-PICOLINE
• CAS No.: 1003711-85-0
• Molecular Formula: C6H5BrClN
• Molecular Weight: 206.469
• Hs Code.: 2933399090
• Mol file: 1003711-85-0.mol

Synonyms:5-Bromo-4-chloro-2-picoline

Chemical Property of 5-BROMO-4-CHLORO-2-PICOLINE

Chemical Property:

• Boiling Point: 223.0±35.0 °C(Predicted)
• PKA: 2.76±0.10(Predicted)
• PSA: 12.89000
• Density: 1.624±0.06 g/cm3(Predicted)
• LogP: 2.80590
• Storage Temp.: Refrigerated.

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-4-chloro-2-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-4-CHLORO-2-PICOLINE

There total 4 articles about 5-BROMO-4-CHLORO-2-PICOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-4-chloro-6-methylpyridine N-oxide (103971-43-3) → 5-bromo-4-chloro-2-methylpyridine (1003711-85-0)

Guidance literature:

3-bromo-4-chloro-6-methylpyridine N-oxide; In chloroform; at 0 ℃; for 3h; Heating / reflux;

With sodium hydrogencarbonate; In chloroform; water;

Reference yield:

5-bromo-2-methylpyridine (3430-13-5) → 5-bromo-4-chloro-2-methylpyridine (1003711-85-0)

Guidance literature:

Multi-step reaction with 4 steps

1: dihydrogen peroxide; acetic acid / water / 72 h / 90 °C

2: sulfuric acid; nitric acid / 48 h / 0 - 90 °C

3: hydrogenchloride / water / 16 h / Heating / reflux

4: chloroform / 3 h / 0 °C / Heating / reflux

With hydrogenchloride; sulfuric acid; dihydrogen peroxide; nitric acid; acetic acid; In chloroform; water;

Reference yield:

5-bromo-2-methyl-pyridine-N-oxide (31181-64-3) → 5-bromo-4-chloro-2-methylpyridine (1003711-85-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; nitric acid / 48 h / 0 - 90 °C

2: hydrogenchloride / water / 16 h / Heating / reflux

3: chloroform / 3 h / 0 °C / Heating / reflux

With hydrogenchloride; sulfuric acid; nitric acid; In chloroform; water;

upstream raw materials:

3-bromo-4-chloro-6-methylpyridine N-oxide

5-bromo-2-methylpyridine

5-bromo-2-methyl-pyridine-N-oxide

5-bromo-2-methyl-4-nitropyridine 1-oxide

Downstream raw materials:

4-chloro-5-(4-chloro-6-methyl-pyridin-3-yl)-2-fluoro-N-(2-methoxy-phenyl)-N-methyl-benzenesulfonamide

Refernces

• 1、 -. "GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO". Page/Page column 41. . Retrieved 2008/12/04.