3-aMino-6-broMo-2-pyridinecarboxylic acid

Base Information

• Chemical Name: 3-aMino-6-broMo-2-pyridinecarboxylic acid
• CAS No.: 1052708-46-9
• Molecular Formula: C6H5BrN2O2
• Molecular Weight: 217.022
• Hs Code.: 2933399090
• Mol file: 1052708-46-9.mol

Synonyms:3-Amino-6-bromopyridine-2-carboxylic acid;

Chemical Property of 3-aMino-6-broMo-2-pyridinecarboxylic acid

Chemical Property:

• Boiling Point: 412.215 °C at 760 mmHg
• PKA: 3.99±0.10(Predicted)
• Flash Point: 203.101 °C
• PSA: 76.21000
• Density: 1.91 g/cm³
• LogP: 1.70570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-Amino-6-bromopicolinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-aMino-6-broMo-2-pyridinecarboxylic acid

There total 3 articles about 3-aMino-6-broMo-2-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 3-amino-6-bromopyridine-2-carboxylate (866775-09-9) → 3-amino-6-bromopyridine-2-carboxylic acid (1052708-46-9)

Guidance literature:

methyl 3-amino-6-bromopyridine-2-carboxylate; With methanol; lithium hydroxide; water; In tetrahydrofuran; for 16h;

With hydrogenchloride; water; In tetrahydrofuran; methanol;

Reference yield:

methyl 3-aminopicolinate (36052-27-4) → 3-amino-6-bromopyridine-2-carboxylic acid (1052708-46-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; bromine / water; acetic acid / 4 h / 10 - 35 °C

2: lithium hydroxide; water / methanol; tetrahydrofuran / 16 h / 10 - 35 °C

With sulfuric acid; water; bromine; lithium hydroxide; In tetrahydrofuran; methanol; water; acetic acid;

Reference yield:

3-amino-pyridine-2-carboxylic acid (1462-86-8) → 3-amino-6-bromopyridine-2-carboxylic acid (1052708-46-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 120 h / Reflux

2: sulfuric acid; bromine / water; acetic acid / 4 h / 10 - 35 °C

3: lithium hydroxide; water / methanol; tetrahydrofuran / 16 h / 10 - 35 °C

With sulfuric acid; water; bromine; lithium hydroxide; In tetrahydrofuran; methanol; water; acetic acid;

upstream raw materials:

methyl 3-amino-6-bromopyridine-2-carboxylate

3-amino-pyridine-2-carboxylic acid

methyl 3-aminopicolinate

Downstream raw materials:

3-amino-6-bromo-N-(4-((1R,3R,4R,5S)-3-(tert-butyldimethylsilyloxy)-4-ethyl-4-hydroxy-5-methylcyclohexyl)pyridin-3-yl)-picolinamide

Refernces

• 1、 -. "ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE THEREOF". Page/Page column 62; 100-101. . Retrieved 2021/01/22.
• 2、 -. "PIM KINASE INHIBITORS AND METHODS OF THEIR USE". Page/Page column 122-123. . Retrieved 2008/12/07.