Technology Process of Trifluoro-acetic acid 2-((2R,4R,4aR,8R,8aS)-8,8a-dimethyl-4-trimethylsilanyloxy-decahydro-naphthalen-2-yl)-1-methoxy-2-phenylselanyl-propyl ester
There total 4 articles about Trifluoro-acetic acid 2-((2R,4R,4aR,8R,8aS)-8,8a-dimethyl-4-trimethylsilanyloxy-decahydro-naphthalen-2-yl)-1-methoxy-2-phenylselanyl-propyl ester which
guide to synthetic route it.
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synthetic route:
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85758-15-2
6β-acetyl-1,2,3,4,4a,5,6,7,8,8a-decahydro-4β,4aβ-dimethyl-8aβ-naphthalen-8-ol
- Guidance literature:
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Multi-step reaction with 3 steps
1: 72 percent / 1.5 h / 150 °C
2: 1.) s-butyl-lithium, 2.) sodium hydride / 1.) THF, cyclohexane, room temperature, 21 h, 2.) THF, room temperature, 42 h
3: diethyl ether / 1.) 0 deg C, 20 min, 2.) room temperature, 1 h
With
sec.-butyllithium; sodium hydride;
In
diethyl ether;
- Guidance literature:
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Multi-step reaction with 4 steps
1: 1.) ozone, 2.) glacial acetic acid, zinc dust / 1.) glacial acetic acid, room temperature, 5.5 h, 2.) 2.5 h
2: 72 percent / 1.5 h / 150 °C
3: 1.) s-butyl-lithium, 2.) sodium hydride / 1.) THF, cyclohexane, room temperature, 21 h, 2.) THF, room temperature, 42 h
4: diethyl ether / 1.) 0 deg C, 20 min, 2.) room temperature, 1 h
With
sec.-butyllithium; sodium hydride; ozone; acetic acid; zinc;
In
diethyl ether;
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85758-18-5
6β-acetyl-1,2,3,4,4a,5,6,7,8,8a-decahydro-4β,4aβ-dimethyl-8β-trimethylsilyloxy-8aβ-naphthalene
- Guidance literature:
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Multi-step reaction with 2 steps
1: 1.) s-butyl-lithium, 2.) sodium hydride / 1.) THF, cyclohexane, room temperature, 21 h, 2.) THF, room temperature, 42 h
2: diethyl ether / 1.) 0 deg C, 20 min, 2.) room temperature, 1 h
With
sec.-butyllithium; sodium hydride;
In
diethyl ether;