4-(Benzyloxy)-1-fluoro-2-nitrobenzene

Base Information

• Chemical Name: 4-(Benzyloxy)-1-fluoro-2-nitrobenzene
• CAS No.: 941867-91-0
• Molecular Formula: C13H10FNO3
• Molecular Weight: 247.226
• Hs Code.: 2909309090
• Mol file: 941867-91-0.mol

Synonyms:4-benzoxy-2-nitro-1-fluorobenzene;4-(BENZYLOXY)-1-FLUORO-2-NITROBENZENE;

Chemical Property of 4-(Benzyloxy)-1-fluoro-2-nitrobenzene

Chemical Property:

• Vapor Pressure: 3.91E-06mmHg at 25°C
• Refractive Index: 1.587
• Boiling Point: 396.4 °C at 760 mmHg
• Flash Point: 193.5 °C
• PSA: 55.05000
• Density: 1.299 g/cm³
• LogP: 3.83610
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-(Benzyloxy)-1-fluoro-2-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Benzyloxy)-1-fluoro-2-nitrobenzene

There total 1 articles about 4-(Benzyloxy)-1-fluoro-2-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

benzyl bromide (100-39-0) + 4-fluoro-3-nitrophenol (2105-96-6) → 4-(benzyloxy)-1-fluoro-2-nitrobenzene (941867-91-0)

Guidance literature:

With potassium carbonate; at 20 ℃; Inert atmosphere;

Reference yield: 81.0%

5-amino-1,3-dihydro-benzoimidazol-2-one (95-23-8) + 4-(benzyloxy)-1-fluoro-2-nitrobenzene (941867-91-0) → 5-((4-(benzyloxy)-2-nitrophenyl)amino)-1,3-dihydro-2H-benzo[d]imidazol-2-one

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 15h;

Reference yield:

4-(benzyloxy)-1-fluoro-2-nitrobenzene (941867-91-0) → 5-(benzyloxy)-2-fluoroaniline (342042-82-4)

Guidance literature:

With methanol; sodium tetrahydroborate; nickel(II) acetate tetrahydrate; In tetrahydrofuran; at 20 ℃; for 1h;

upstream raw materials:

benzyl bromide

4-fluoro-3-nitrophenol

Downstream raw materials:

5-(benzyloxy)-2-fluoroaniline

Refernces

• 1、 -. "COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR". Paragraph 0241. . Retrieved 2017/08/01.