5-Chloroisoindoline hydrochloride

Base Information

• Chemical Name: 5-Chloroisoindoline hydrochloride
• CAS No.: 912999-79-2
• Molecular Formula: C8H9Cl2N
• Molecular Weight: 190.072
• Hs Code.: 2933990090
• Mol file: 912999-79-2.mol

Synonyms:5-chloro-2,3-dihydro-1H-isoindole,hydrochloride

Chemical Property of 5-Chloroisoindoline hydrochloride

Chemical Property:

• PSA: 12.03000
• LogP: 3.07400
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99.0% ^*data from raw suppliers

5-Chloroisoindolinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Chloroisoindoline hydrochloride

There total 2 articles about 5-Chloroisoindoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-2-p-tosylisoindoline (127168-77-8) → 5-chloro-2,3-dihydro-1H-isoindole hydrochloride (912999-79-2)

Guidance literature:

With hydrogen bromide; phenol; In water; propionic acid; for 6h; Heating / reflux;

Reference yield:

5-chloro-2,3-dihydro-1H-isoindole (127168-76-7) → 5-chloro-2,3-dihydro-1H-isoindole hydrochloride (912999-79-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 0.25h;

Reference yield:

5-chloro-2,3-dihydro-1H-isoindole hydrochloride (912999-79-2) + 4-(ethoxycarbonyl)-1-(4-methoxybenzyl)-1H-1,2,3-triazole-5-carboxylic acid → C22H21ClN4O4

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

5-chloro-2,3-dihydro-1H-isoindole

5-chloro-2-p-tosylisoindoline

Downstream raw materials:

C₃₂H₂₈ClNO₃

Refernces

• 1、 -. "PHARMACEUTICAL COMBINATIONS". Page/Page column 205. . Retrieved 2008/06/13.
• 2、 -. "PHARMACEUTICAL COMBINATIONS". Page/Page column 227. . Retrieved 2008/06/13.