4-Bromoisoindoline-1,3-dione

Base Information

• Chemical Name: 4-Bromoisoindoline-1,3-dione
• CAS No.: 70478-63-6
• Molecular Formula: C8H4BrNO2
• Molecular Weight: 226.029
• Hs Code.: 2925190090
• Mol file: 70478-63-6.mol

Synonyms:1H-isoindole-1,3(2H)-dione, 4-bromo-;3-Bromophthalimide;4-Bromo-1H-isoindole-1,3(2H)-dione;

Chemical Property of 4-Bromoisoindoline-1,3-dione

Chemical Property:

• Melting Point: 260 °C
• Refractive Index: 1.65
• PKA: 9.15±0.20(Predicted)
• PSA: 49.66000
• Density: 1.827 g/cm³
• LogP: 1.34310
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromoisoindoline-1,3-dione >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromoisoindoline-1,3-dione

There total 5 articles about 4-Bromoisoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-bromophthalic anhydride (82-73-5) → 6-bromophthalimide (70478-63-6)

Guidance literature:

With formamide; at 200 ℃; for 2h; Inert atmosphere;

Reference yield: 51.0%

4-bromo-2-methylisoindoline-1,3-dione (64954-16-1) + 6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-amine (1448427-99-3) → 6-bromophthalimide (70478-63-6)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; XPhos; In 1,4-dioxane; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

3-aminophthalimide (2518-24-3) → 6-bromophthalimide (70478-63-6)

Guidance literature:

With sulfuric acid; water; sodium nitrite; at 100 ℃; Diazotization_.beim Erhitzen der Diazoniumsalz-Loesung mit Kupfer(I)-bromid und Bromwasserstoffsaeure;

DOI:10.1039/jr9390000836

upstream raw materials:

3-aminophthalimide

3-bromophthalic acid

4-bromo-2-methylisoindoline-1,3-dione

6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-amine

Downstream raw materials:

5-bromo-2-methyl-2,3-dihydro-1H-isoindole-1,3-dione

Refernces

• 1、 -. "APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK 1) INHIBITOR COMPOUNDS". Paragraph 00291. . Retrieved 2019/04/27.