4-BROMO-2-METHYL-1H-BENZIMIDAZOLE

Base Information

• Chemical Name: 4-BROMO-2-METHYL-1H-BENZIMIDAZOLE
• CAS No.: 20223-87-4
• Molecular Formula: C8H7BrN2
• Molecular Weight: 211.061
• Hs Code.: 2933990090
• Mol file: 20223-87-4.mol

Synonyms:4-BROMO-2-METHYL-1H-BENZIMIDAZOLE;4-Bromo-2-methylbenzimidazole;4-BroMo-2-Methyl-1H-benzo[d]iMidazole

Chemical Property of 4-BROMO-2-METHYL-1H-BENZIMIDAZOLE

Chemical Property:

• Boiling Point: 397.3 °C at 760 mmHg
• PKA: 9.44±0.30(Predicted)
• Flash Point: 194.1 °C
• PSA: 28.68000
• Density: 1.654 g/cm³
• LogP: 2.63380
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromo-2-methyl-1H-benzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-2-METHYL-1H-BENZIMIDAZOLE

There total 4 articles about 4-BROMO-2-METHYL-1H-BENZIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-bromobenzene-1,2-diamine (1575-36-6) + Triethyl orthoacetate (78-39-7) → 4-bromo-2-methyl-1H-benzo[d]imidazole (20223-87-4)

Guidance literature:

With 1,1,1,3',3',3'-hexafluoro-propanol; at 20 ℃; for 16h;

DOI:10.1021/ol4017723

Reference yield:

3-bromobenzene-1,2-diamine (1575-36-6) + acetic anhydride (108-24-7) → 4-bromo-2-methyl-1H-benzo[d]imidazole (20223-87-4)

Guidance literature:

With oxonium; Yield given. Multistep reaction; 1) 110 deg C, 2) 100 deg C, 3 h;

DOI:10.1016/S0040-4039(98)00249-4

Reference yield:

3-bromobenzene-1,2-diamine (1575-36-6) + acetic acid (64-19-7,77671-22-8) → 4-bromo-2-methyl-1H-benzo[d]imidazole (20223-87-4)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

3-bromobenzene-1,2-diamine

acetic acid

acetic anhydride

Triethyl orthoacetate

Downstream raw materials:

4-Bromo-1-(4-tert-butyl-benzyl)-2-methyl-1H-benzoimidazole

1-benzyl-4-bromo-2-methyl-1H-benzo[d]imidazole

3-[4-(1-benzyl-2-methyl-1H-benzimidazol-4-yl)phenyl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

[1-(4-tert-Butyl-benzyl)-2-methyl-1H-benzoimidazol-4-yl]-phenyl-phosphinic acid ethyl ester

Refernces

• 1、 Kato, Jun-Ya,Ito, Yutaro,Ijuin, Ryosuke,Aoyama, Hiroshi,Yokomatsu, Tsutomu. "Novel strategy for synthesis of substituted benzimidazo[1,2-a]quinolines". supporting information. p. 3794 - 3797. Retrieved 2013/08/23.