2-Chloro-4-methoxynitrobenzene

Base Information

• Chemical Name: 2-Chloro-4-methoxynitrobenzene
• CAS No.: 28987-59-9
• Molecular Formula: C7H6ClNO3
• Molecular Weight: 187.583
• Hs Code.: 2909309090
• Mol file: 28987-59-9.mol

Synonyms:3-Chloro-4-nitrophenyl methyl ether;

Chemical Property of 2-Chloro-4-methoxynitrobenzene

Chemical Property:

• Vapor Pressure: 0.00177mmHg at 25°C
• Boiling Point: 302.5 °C at 760 mmHg
• Flash Point: 136.7 °C
• PSA: 55.05000
• Density: 1.366 g/cm³
• LogP: 2.78000
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-4-methoxy-1-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4-methoxynitrobenzene

There total 12 articles about 2-Chloro-4-methoxynitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-chloro-4-fluoro-1-nitrobenzene (2106-50-5) + sodium methylate (124-41-4) → 3-chloro-4-nitroanisole (28987-59-9)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield: 92.0%

3-chloro-4-nitrophenol (491-11-2) + dimethyl sulfate (77-78-1) → 3-chloro-4-nitroanisole (28987-59-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 3h; Heating;

DOI:10.1021/jo00220a024

Reference yield: 85.5%

2,4-dichloronitrobenzene (611-06-3) + sodium methylate (124-41-4) → 3-chloro-4-nitroanisole (28987-59-9)

Guidance literature:

In methanol; at 68 ℃;

upstream raw materials:

3-chloro-4-nitrophenol

dimethyl sulfate

methyl iodide

1-chloro-3-methoxy-benzene

Downstream raw materials:

2-Amino-4-chlor-5'-methoxy-2'-nitro-diphenylsulfid

4-nitroresorcinol

3-chloro-4-nitrophenol

4-chloro-6-methoxy-1,3-benzothiazol-2-amine

Refernces

• 1、 -. "Benzotriazine compound with PAR4 antagonistic activity and application thereof". Paragraph 0059; 0061-0062. . Retrieved 2020/08/02.
• 2、 -. "BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS". Page/Page column 454. . Retrieved 2018/03/25.