2-(Piperidin-2-yl)pyridine

Base Information

• Chemical Name: 2-(Piperidin-2-yl)pyridine
• CAS No.: 15578-73-1
• Molecular Formula: C10H14N2
• Molecular Weight: 162.235
• European Community (EC) Number: 862-795-8
• Nikkaji Number: J503.683F
• Mol file: 15578-73-1.mol

Synonyms:2-(piperidin-2-yl)pyridine;15578-73-1;2-piperidin-2-ylpyridine;2-(2-Piperidinyl)pyridine;1,2,3,4,5,6-hexahydro-[2,2']bipyridinyl;1,2,3,4,5,6-HEXAHYDRO-[2,2/']BIPYRIDINYL;Pyridine, 2-(2-piperidinyl)-;2-(2-piperidyl)pyridine;SCHEMBL1784909;WBA04169;BBL020492;MFCD02663547;STK893188;2-Piperidin-2-ylpyridine, AldrichCPR;AKOS001475982;SB42264;SB45850;SB46833;CS-0206807;FT-0683095;N10817;EN300-1726245;A903293

Chemical Property of 2-(Piperidin-2-yl)pyridine

Chemical Property:

• Vapor Pressure: 0.00378mmHg at 25°C
• Refractive Index: 1.524
• Boiling Point: 280.4 °C at 760 mmHg
• PKA: 8.88±0.10(Predicted)
• Flash Point: 123.4 °C
• PSA: 24.92000
• Density: 1.014 g/cm³
• LogP: 2.22500
• Storage Temp.: 2-8°C
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 162.115698455
• Heavy Atom Count: 12
• Complexity: 136

Purity/Quality:

98%Min ^*data from raw suppliers

2-(Piperidin-2-yl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCNC(C1)C2=CC=CC=N2

Technology Process of 2-(Piperidin-2-yl)pyridine

There total 9 articles about 2-(Piperidin-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-[1-(phenylmethyl)-2-piperidinyl]pyridine (1061659-64-0) → 2-(2'-Piperidinyl)pyridine (15578-73-1,5746-87-2)

Guidance literature:

With hydrogen; palladium hydroxide - carbon; In ethanol; at 20 ℃; for 48h; under 2280.15 - 3040.2 Torr;

DOI:10.1016/j.tetasy.2008.06.005

Reference yield: 60.0%

2,2'-bipyridyl N-oxide (33421-43-1) → 2-(2'-Piperidinyl)pyridine (15578-73-1,5746-87-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 16h;

Reference yield: 27.0%

[2,2]bipyridinyl (366-18-7) → 2,2'-bipiperidine (531-67-9) + 2-(2'-Piperidinyl)pyridine (15578-73-1,5746-87-2)

Guidance literature:

With Cp*Rh(2-(2-pyridyl)phenyl)H; hydrogen; In neat (no solvent); at 100 ℃; for 48h; under 27361.8 Torr; Catalytic behavior; Glovebox;

DOI:10.1021/jacs.9b09540

upstream raw materials:

[2,2]bipyridinyl

2,2'-bipyridyl N-oxide

2-[1-(phenylmethyl)-2-piperidinyl]pyridine

5-bromopentan-1-nitrile

Downstream raw materials:

4-(1H-indol-3-ylmethyl)-6-{2-oxo-2-[(2R)-2-pyridin-2-ylpiperidin-1-yl]ethyl}-1-phenyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one

C₂₂H₂₂Cl₂N₄O₂

[2,2]bipyridinyl

Refernces

• 1、 Plaquevent, Jean-Christophe,Chichaoui, Ilhame. "Reduction Regiospecifique des Bipyridines". . p. 5287 - 5288. Retrieved 1993.
• 2、 Cochrane, Edward J.,Leonori, Daniele,Hassall, Lorraine A.,Coldham, Iain. "Synthesis and kinetic resolution of N-Boc-2-arylpiperidines". . p. 9910 - 9913. Retrieved 2014/08/18.