(1S-trans)-1,2-Cyclohexanediamine dihydrochloride

Base Information

• Chemical Name: (1S-trans)-1,2-Cyclohexanediamine dihydrochloride
• CAS No.: 35018-62-3
• Molecular Formula: C6H14N2.2(HCl)
• Molecular Weight: 187
• Hs Code.: 2921300090
• Mol file: 35018-62-3.mol

Synonyms:(1S,2S)-1,2-Cyclohexanediamine hydrochloride;(1S-trans)-1,2-Cyclohexanediamine dihydrochloride;1,2-Cyclohexanediamine, hydrochloride (1:2), (1S,2S)-;1,2-CyclohexanediaMine, N1,N2-diMethyl-, dihydrochloride, (1S,2S)-

Chemical Property of (1S-trans)-1,2-Cyclohexanediamine dihydrochloride

Chemical Property:

• PSA: 52.04000
• LogP: 2.41760

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S-trans)-1,2-Cyclohexanediamine dihydrochloride

There total 13 articles about (1S-trans)-1,2-Cyclohexanediamine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-[(1R,2R)-2-(2-Methoxycarbonyl-acetylamino)-cyclohexyl]-malonamic acid methyl ester (186144-56-9) → (1R,2R)-1,2-dicyclohexane-1,2-diamine dihydrochloride (10027-80-2,10027-83-5,32044-18-1,32044-21-6,35018-62-3,35018-63-4,73571-37-6,78020-70-9,78995-00-3)

Guidance literature:

With hydrogenchloride; at 110 ℃; for 3h;

DOI:10.1016/S0957-4166(99)00010-5

Reference yield: 98.0%

(1R,2R)-1,2-diaminocyclohexane tartrate (32044-22-7,39961-95-0) → (1R,2R)-1,2-dicyclohexane-1,2-diamine dihydrochloride (10027-80-2,10027-83-5,32044-18-1,32044-21-6,35018-62-3,35018-63-4,73571-37-6,78020-70-9,78995-00-3)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1021/ja8002777

Reference yield: 96.0%

(R,R)-1,2-diaminocyclohexane tartrate (32044-22-7,39961-95-0) → (1R,2R)-1,2-dicyclohexane-1,2-diamine dihydrochloride (10027-80-2,10027-83-5,32044-18-1,32044-21-6,35018-62-3,35018-63-4,73571-37-6,78020-70-9,78995-00-3)

Guidance literature:

With hydrogenchloride; In diethyl ether;

DOI:10.1016/S0040-4020(97)00134-8

upstream raw materials:

2-aminocyclohexanecarboxamide

2-amino-cyclohexanecarboxylic acid ethyl ester

1,2-dinitrocyclohexane

(R,R)-1,2-diaminocyclohexane tartrate

Downstream raw materials:

1,2-dinitrocyclohexane

(1R,2R)-N-(2,4-Dinitro-phenyl)-cyclohexane-1,2-diamine

2,2'-(1E,1'E)-(1R,2R)-cyclohexane-1,2-diylbis(azan-1-yl-1-ylidene)bis(methan-1-yl-1-ylidene)diphenol

(S,S)-N,N'-bis(p-tolylsulfonyl)-trans-cyclohexane-1,2-diamine

Refernces

• 1、 Rivera, Augusto,Quiroga, Diego,Jiménez-Cruz, Leonardo,Fejfarová, Karla,Du?ek, Michal. "New cyclic aminals derived from rac-trans-1,2-diaminocyclohexane: Synthesis and crystal structure of racemic 1,8,10,12-tetraazatetracyclo[8.3.1.1. 8,1202,7] pentadecane and a route to its enantiomerically pure (R,R) and (S,S) isomers". body text. p. 345 - 348. Retrieved 2012/02/01.
• 2、 Peruncheralathan, Saravanan,Teller, Henrik,Schneider, Christoph. "Titanium binolate catalyzed aminolysis of meso aziridines: A highly enantioselective and direct access to 1,2-diamines". scheme or table. p. 4849 - 4852. Retrieved 2009/10/30.