tert-Butyl 4-amino-3-methyl-1-piperidinecarboxylate

Base Information

• Chemical Name: tert-Butyl 4-amino-3-methyl-1-piperidinecarboxylate
• CAS No.: 900642-17-3
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.308
• Hs Code.: 2933399090
• Mol file: 900642-17-3.mol

Synonyms:tert-butyl 4-amino-3-methylpiperidine-1-carboxylate

Chemical Property of tert-Butyl 4-amino-3-methyl-1-piperidinecarboxylate

Chemical Property:

• Boiling Point: 287.8 °C at 760 mmHg
• PKA: 10.12±0.40(Predicted)
• Flash Point: 127.8 °C
• PSA: 55.56000
• Density: 1.009 g/cm³
• LogP: 2.22880
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl4-amino-3-methylpiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 4-amino-3-methyl-1-piperidinecarboxylate

There total 2 articles about tert-Butyl 4-amino-3-methyl-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate (181269-69-2) → tert-butyl 4-amino-3-methylpiperidine-1-carboxylate (900642-17-3,1428341-13-2)

Guidance literature:

With ammonium formate; sodium cyanoborohydride; In methanol; at 30 ℃; for 16h; Temperature; Molecular sieve;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → tert-butyl 4-amino-3-methylpiperidine-1-carboxylate (900642-17-3,1428341-13-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 20 °C

2: ammonium formate; sodium cyanoborohydride / methanol / 3 h / 20 °C / Molecular sieve

With ammonium formate; sodium hydride; sodium cyanoborohydride; In tetrahydrofuran; methanol; mineral oil;

Reference yield: 90.92%

tert-butyl 4-amino-3-methylpiperidine-1-carboxylate (900642-17-3,1428341-13-2) → 3-methylpiperidin-4-amine (396133-35-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

upstream raw materials:

tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

(rac)-(cis/trans)-3-methyl-4-phenylacetylamino-piperidine-1-carboxylic acid tert-butyl ester

3-methylpiperidin-4-amine

(rac)-(cis/trans)-N-(3-methyl-piperidin-4-yl)-2-phenyl-acetamide

Refernces

• 1、 -. "SUBSTITUTED PIPERIDINE COMPOUNDS". Paragraph 0309. . Retrieved 2016/06/01.