3-BocaMino-4-chloropyridine

Base Information

• Chemical Name: 3-BocaMino-4-chloropyridine
• CAS No.: 1068976-14-6
• Molecular Formula: C10H13ClN2O2
• Molecular Weight: 228.68
• Hs Code.: 2933399090
• Mol file: 1068976-14-6.mol

Synonyms:tert-Butyl 4-Chloropyridin-3-ylcarbamate;

Chemical Property of 3-BocaMino-4-chloropyridine

Chemical Property:

• PSA: 51.22000
• LogP: 3.15500
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl4-Chloropyridin-3-ylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BocaMino-4-chloropyridine

There total 4 articles about 3-BocaMino-4-chloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

3-(tert-butoxycarbonylamino)pyridine (56700-70-0) → tert-butyl (4-chloropyridin-3-yl)carbamate (1068976-14-6)

Guidance literature:

3-(tert-butoxycarbonylamino)pyridine; With n-butyllithium; In 1,2-dimethoxyethane; hexane; at -78 - -20 ℃; for 2h;

With hexachloroethane; In 1,2-dimethoxyethane; hexane; at -78 ℃;

DOI:10.1021/acs.joc.7b02966

Reference yield: 46.0%

3-amino-4-chloropyridine (20511-15-3) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (4-chloropyridin-3-yl)carbamate (1068976-14-6)

Guidance literature:

3-amino-4-chloropyridine; With lithium hexamethyldisilazane; In tetrahydrofuran; at -10 ℃; for 1h;

di-tert-butyl dicarbonate; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

pyridin-3-ylamine (462-08-8) → tert-butyl (4-chloropyridin-3-yl)carbamate (1068976-14-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: isopropyl alcohol; water / 0 °C

2.1: n-butyllithium / 1,2-dimethoxyethane; hexane / 2 h / -78 - -20 °C

2.2: -78 °C

With n-butyllithium; In 1,2-dimethoxyethane; hexane; water; isopropyl alcohol;

DOI:10.1021/acs.joc.7b02966

upstream raw materials:

3-(tert-butoxycarbonylamino)pyridine

pyridin-3-ylamine

di-tert-butyl dicarbonate

3-amino-4-chloropyridine

Refernces

• 1、 -. "FUSED PYRIDINES AS KINASE INHIBITORS". Paragraph 0140. . Retrieved 2018/06/04.