2-Amino-6-chloroimidazo[1,2-b]pyridazine

Base Information

• Chemical Name: 2-Amino-6-chloroimidazo[1,2-b]pyridazine
• CAS No.: 887625-09-4
• Molecular Formula: C6H5ClN4
• Molecular Weight: 168.585
• Hs Code.: 2933990090
• Mol file: 887625-09-4.mol

Synonyms:6-chloroimidazo[1,2-b]pyridazin-2-amine;Imidazo[1,2-b]pyridazin-2-amine, 6-chloro-;

Chemical Property of 2-Amino-6-chloroimidazo[1,2-b]pyridazine

Chemical Property:

• Refractive Index: 1.791
• PKA: 7.03±0.30(Predicted)
• PSA: 56.21000
• Density: 1.715 g/cm³
• LogP: 1.54610
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-6-chloroimidazo[1,2-b]pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-6-chloroimidazo[1,2-b]pyridazine

There total 6 articles about 2-Amino-6-chloroimidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl (6-chloroimidazo[1,2-b]pyridazin-2-yl)carbamate → 6-chloroimidazo[1,2-b]pyridazine-2-amine (887625-09-4)

Guidance literature:

tert-butyl (6-chloroimidazo[1,2-b]pyridazin-2-yl)carbamate; With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 20 ℃;

With sodium hydroxide; In water; pH=7;

DOI:10.1002/bkcs.12275

Reference yield: 90.0%

N-(6-chloroimidazo[1,2-b]pyridazin-2-yl)-2,2,2-trifluoroacetamide (947248-50-2) → 6-chloroimidazo[1,2-b]pyridazine-2-amine (887625-09-4)

Guidance literature:

With methanol; water; potassium carbonate; In tetrahydrofuran; for 8h; Product distribution / selectivity; Heating / reflux;

Reference yield: 87.0%

(Z)-2-(3-chloro-6-((phenylsulfonyl)imino)pyridazin-1(6H)-yl)acetamide → 6-chloroimidazo[1,2-b]pyridazine-2-amine (887625-09-4)

Guidance literature:

(Z)-2-(3-chloro-6-((phenylsulfonyl)imino)pyridazin-1(6H)-yl)acetamide; With trifluoroacetic anhydride; In dichloromethane; at 50 ℃; for 6h;

With potassium carbonate; In tetrahydrofuran; water; at 70 ℃;

DOI:10.1016/j.ejmech.2021.114036

upstream raw materials:

azido(6-chloroimidazo[1,2-b]pyridazin-2-yl)methanone

N-(6-chloroimidazo[1,2-b]pyridazin-2-yl)-2,2,2-trifluoroacetamide

(Z)-2-(3-chloro-6-(tosylimino)pyridazin-1(6H)-yl)acetamide

Refernces

• 1、 Lee, Yujin,Jang, Jiyoon,Bibi, Maimoona,Duggirala, Krishna Babu,Ji, Sang Hee,Lee, Ji Hun,Ahn, Sunjoo,Song, Jin Sook,Chae, Chong Hak,Kim, Seong Hwan,Lee, Kwangho. "Rational Design, Synthesis and Evaluation of Novel C6-Bicycloalkaneimidazole Containing Imidazo[1,2-b]pyridazines for ASK1 Inhibition". . p. 872 - 877. Retrieved 2021/05/10.
• 2、 -. "FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE". Page/Page column 163-164. . Retrieved 2010/09/18.