C₂₉H₃₉N₅O₄

Base Information

• Chemical Name: C₂₉H₃₉N₅O₄
• CAS No.: 1307864-99-8
• Molecular Formula: C₂₉H₃₉N₅O₄
• Molecular Weight: 521.66
• Mol file: 1307864-99-8.mol

Synonyms:

Chemical Property of C₂₉H₃₉N₅O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₉H₃₉N₅O₄

There total 10 articles about C₂₉H₃₉N₅O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-5-methylpyridin-2-amine (17282-00-7) → C29H39N5O4 (1307864-99-8)

Guidance literature:

Multi-step reaction with 9 steps

1.1: dichloromethane / 20 °C

2.1: methanesulfonyl chloride; triethylamine

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-ethyl-N,N-diisopropylamine

3.2: 20 °C

4.1: toluene / 4 h / Reflux; Molecular sieve; Inert atmosphere

5.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 85 °C

7.1: sodium tetrahydroborate; lithium chloride / tetrahydrofuran; ethanol / 24 h / 20 °C

8.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

9.1: piperidine / dichloromethane

With piperidine; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene; acetonitrile;

DOI:10.1021/mp200007b

Reference yield:

C21H22N4O2 → C29H39N5O4 (1307864-99-8)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 85 °C

3: sodium tetrahydroborate; lithium chloride / tetrahydrofuran; ethanol / 24 h / 20 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

5: piperidine / dichloromethane

With piperidine; dmap; sodium tetrahydroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;

DOI:10.1021/mp200007b

Reference yield:

9-acetyl-7-methyl-2-(morpholin-4-yl)-4H-pyrido[1,2-a]pyrimidin-4-one → C29H39N5O4 (1307864-99-8)

Guidance literature:

Multi-step reaction with 6 steps

1: toluene / 4 h / Reflux; Molecular sieve; Inert atmosphere

2: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 85 °C

4: sodium tetrahydroborate; lithium chloride / tetrahydrofuran; ethanol / 24 h / 20 °C

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

6: piperidine / dichloromethane

With piperidine; dmap; sodium tetrahydroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene; acetonitrile;

DOI:10.1021/mp200007b

upstream raw materials:

7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one

TGX-D₁

C₂₄H₂₈N₄O₄

Fmoc-Leu-OH

Downstream raw materials:

TGX-D₁

NH₂-SL-TGX

Refernces