Mk-2461 .

Base Information

• Chemical Name: Mk-2461 .
• CAS No.: 917879-39-1
• Molecular Formula: C24H25N5O5S
• Molecular Weight: 495.557
• Mol file: 917879-39-1.mol

Synonyms:Mk-2461 .;N-[(2R)-1,4-dioxan-2-ylMethyl]-N-Methyl{[5-(1-Methyl-1H-pyrazol-4-yl)-2-oxo-7-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-14-yl]aMino}sulfonaMide;N-((2R)-1,4-Dioxan-2-ylmethyl)-N-methyl-N-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]sulfamide

Chemical Property of Mk-2461 .

Chemical Property:

• Melting Point: 192-193 °C
• Boiling Point: 732.4 °C at 760 mmHg
• PKA: 6.81±0.20(Predicted)
• Flash Point: 396.7 °C
• PSA: 124.03000
• Density: 1.45 g/cm³
• LogP: 3.30640
• Solubility.: ≥24.8 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

Purity/Quality:

98%,99%, ^*data from raw suppliers

MK-2461 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: MK-2461 is a potent inhibitor of c-Met, Ron, Flt1/3, PDGFRβ, Mer and FGFR1/2/3 with IC50 of 2.5 nM, 7 nM, 10 nM/22 nM, 22 nM, 24 nM and 65 nM/39 nM/50 nM, respectively. MK-2461 is a novel ATP-competitive multitargeted kinase inhibitor that preferentially inhibits the activated c-Met receptor. MK-2461 is also a potent inhibitor of Ron, Flt1, Flt 3, PDGFRβ, and Mer receptors. Recent studies show that MK-2461 siginifciantly suppresses tumor growth of GTL-16 xenografts in mice and MK-2461 treatments effectively inhibit the growth of NIH3T3 tumors harboring c-Met single nucleotide mutants T3936C and T3997C.