NVP-BEP800

Base Information

• Chemical Name: NVP-BEP800
• CAS No.: 847559-80-2
• Molecular Formula: C₂₁H₂₃Cl₂N₅O₂S
• Molecular Weight: 480.418
• Mol file: 847559-80-2.mol

Synonyms:VER-82576;

Chemical Property of NVP-BEP800

Chemical Property:

• PSA: 122.34000
• Density: 1.396 g/cm³
• LogP: 4.73050
• Solubility.: insoluble in H2O; ≥16 mg/mL in EtOH with gentle warming; ≥24.7 mg/mL in DMSO with gentle warming and ultrasonic

Purity/Quality:

99% ^*data from raw suppliers

NVP-BEP 800 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: NVP-BEP 800 is a Hsp90 inhibitor which ehibits anti-proliferative effects against cancer cell lines with high expression level of Hsp90.

Technology Process of NVP-BEP800

There total 2 articles about NVP-BEP800 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-amino-4-(2,4-dichloro-5-hydroxyphenyl)thieno[2,3-d]pyrimidine-6-carboxylic acid ethylamide (847559-68-6) + 1-(2-chloroethyl)pyrrolidine hydrochloride (7250-67-1) → 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-yl-ethoxy)phenyl]thieno[2,3-d]pyrimidine-6-carboxylic acid ethylamide (847559-80-2)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; Heating;

DOI:10.1021/jm900357y

Reference yield:

→ 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-yl-ethoxy)phenyl]thieno[2,3-d]pyrimidine-6-carboxylic acid ethylamide (847559-80-2)

Guidance literature:

upstream raw materials:

2-amino-4-(2,4-dichloro-5-hydroxyphenyl)thieno[2,3-d]pyrimidine-6-carboxylic acid ethylamide

1-(2-chloroethyl)pyrrolidine hydrochloride

Refernces

• 1、 -. "PYRIMIDOTHIOPHENE COMPOUNDS". Page/Page column 83. . Retrieved 2010/02/11.