Farampator

Base Information

• Chemical Name: Farampator
• CAS No.: 211735-76-1
• Deprecated CAS: 224047-75-0
• Molecular Formula: C12H13N3O2
• Molecular Weight: 231.254
• UNII: 7X6P5N8K2L
• DSSTox Substance ID: DTXSID90175413
• Nikkaji Number: J2.510.656C
• Wikipedia: Farampator
• Wikidata: Q5434818
• NCI Thesaurus Code: C65620
• Metabolomics Workbench ID: 155231
• ChEMBL ID: CHEMBL1276138
• Mol file: 211735-76-1.mol

Synonyms:1-(benzofurazan-5-ylcarbonyl)piperidine;5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole;CX-691;farampator;Org 24448

Chemical Property of Farampator

Chemical Property:

• PSA: 59.23000
• LogP: 1.78680
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 231.100776666
• Heavy Atom Count: 17
• Complexity: 292

Purity/Quality:

98%Min ^*data from raw suppliers

Farampator ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C(=O)C2=CC3=NON=C3C=C2
• Recent ClinicalTrials: Org 24448 (Ampakine) for Cognitive Deficits in Schizophrenia
• Recent EU Clinical Trials: A multi-center cardiac safety study of subjects who participated in Organon sponsored Phase 1 and Phase 2 completed and discontinued trials with Org 24448 (Protocols: 22601;22602;22603; 153001;153002;153003;153004, 29402; III.04.0311).
• Uses: Farampator has shown effects as an AMPA receptor potentiator and glycine reuptake inhibitor with potential anti-psychotic efficacy and enhancement of prefrontal glutamatergic transmission. Farampator’ s effects on both AMPA-PAMs and GlyT-1 inhibitor maybe also improve cognitive impairments in schizophrenia and in particular when combied with Risperidone (R525000). Farampator has shown effects as an AMPA receptor potentiator and glycine reuptake inhibitor with potential anti-psychotic efficacy and enhancement of prefrontal glutamatergic transmission. Farampator’s effects on both AMPA-PAMs and GlyT-1 inhibitor maybe also improve cognitive impairments in schizophrenia and in particular when combied with Risperidone (R525000).

Technology Process of Farampator

There total 3 articles about Farampator which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

piperidine (110-89-4) + benzo[c][1,2,5]oxadiazole-5-carboxylic acid (19155-88-5) + 1,1'-carbonyldiimidazole (530-62-1) → CX691 (211735-76-1)

Guidance literature:

In dichloromethane;

Reference yield: 60.0%

piperidine (110-89-4) + methyl benzo[c][1,2,5]oxadiazole-5-carboxylate → CX691 (211735-76-1)

Guidance literature:

With potassium phosphate; 2,2,2-trifluoroethanol; In tetrahydrofuran; at 90 ℃; for 22h; Sealed tube;

DOI:10.1039/c5cc02895g

Reference yield:

1-(4-chloro-3-nitro-benzoyl)-piperidine (91721-46-9) → CX691 (211735-76-1)

Guidance literature:

In ethylene glycol;

upstream raw materials:

piperidine

benzo[c][1,2,5]oxadiazole-5-carboxylic acid

1,1'-carbonyldiimidazole

1-(4-chloro-3-nitro-benzoyl)-piperidine

Refernces

• 1、 -. "Benzofurazan compounds which enhance AMPA receptor activity". . . Retrieved 2008/06/13.