5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine
• CAS No.: 870483-87-7
• Molecular Formula: C20H22N4O3
• Molecular Weight: 366.41
• Hs Code.: 2933599090
• European Community (EC) Number: 809-788-8
• UNII: SRV0JCF9LI
• ChEMBL ID: CHEMBL261849
• DSSTox Substance ID: DTXSID10236095
• Nikkaji Number: J2.963.174C
• Pharos Ligand ID: 8Q2RBAFMVF64
• Wikidata: Q27077940
• Mol file: 870483-87-7.mol

Synonyms:5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine;GW 2580;GW-2580;GW2580

Chemical Property of 5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine

Chemical Property:

• PSA: 105.51000
• LogP: 3.99040
• Storage Temp.: ?20°C
• Solubility.: DMSO: soluble10mg/mL, clear (warmed)
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 7
• Exact Mass: 366.16919058
• Heavy Atom Count: 27
• Complexity: 433

Purity/Quality:

98%,99%, ^*data from raw suppliers

GW 2580 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)COC2=C(C=C(C=C2)CC3=CN=C(N=C3N)N)OC
• Description: GW-2580 (870483-87-7) is a potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity against 26 other kinases1. Completely inhibits CSF-1 induced growth of mouse M-NFS-60 myeloid cells and human monocytes (at 1 μM)1. GW-2580 completely inhibits bone degradation in human osteoclasts, rat calvaria and fetal long bone1. Inhibits LPS-induced TNF production in mice. GW-2580 abrogates infiltration of macrophages into synovial joints of arthritic mice2. Active in vivo.
• Uses: GW2580 has been used to study its effect on paracrine signaling from stretched cardiomyocyte on cardiac fibroblast phenotype.