LRRK2-IN-1

Base Information

• Chemical Name: LRRK2-IN-1
• CAS No.: 1234480-84-2
• Molecular Formula: C31H38N8O3
• Molecular Weight: 570.695
• Mol file: 1234480-84-2.mol

Synonyms:5,11-Dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one;2-((2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one;

Chemical Property of LRRK2-IN-1

Chemical Property:

• Boiling Point: 787.818 °C at 760 mmHg
• PKA: 8.14±0.42(Predicted)
• Flash Point: 430.257 °C
• PSA: 100.76000
• Density: 1.279 g/cm³
• LogP: 2.87330
• Solubility.: ≥28.55 mg/mL in DMSO; insoluble in H2O; ≥57.2 mg/mL in EtOH

Purity/Quality:

99% ^*data from raw suppliers

LRRK2-IN-1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson''s disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. LRRK2-IN-1 is a potent inhibitor of LRRK2 that inhibits both wild-type and G2019S mutant LRRK2 (IC50s = 13 and 6 nM, respectively). It is selective for LRRK2 over a large panel of other kinases. LRRK2-IN-1 treatment causes dephosphorylation of LRRK2, leading to its dissociation from 14-3-3 proteins, ubiquitination, and degradation. Inhibitors of LRRK2, including LRRK2-IN-1, stimulate macroautophagy in H4 neuroglioma cells.
• Uses: LRRK2-IN-1 is a benzodiazepine based derivative and is known as a selective inhibitor of the Parkinson''s disease kinase LRRK2.