MK-6892

Base Information

• Chemical Name: MK-6892
• CAS No.: 917910-45-3
• Molecular Formula: C₁₉H₂₂N₄O₅
• Molecular Weight: 386.407
• Mol file: 917910-45-3.mol

Synonyms:MK-6892;CS-2425;MK 6892;MK6892;2-[[3-[3-(5-Hydroxy-2-pyridinyl)-1,2,4-oxadiazol-5-yl]-2,2-dimethyl-1-oxopropyl]amino]-1-cyclohexene-1-carboxylic acid;1-Cyclohexene-1-carboxylic acid, 2-[[3-[3-(5-hydroxy-2-pyridinyl)-1,2,4-oxadiazol-5-yl]-2,2-dimethyl-1-oxopropyl]amino]-

Chemical Property of MK-6892

Chemical Property:

• PSA: 141.93000
• LogP: 3.27510
• Solubility.: ≥34.9 mg/mL in DMSO; ≥3.41 mg/mL in EtOH with ultrasonic; insoluble in H2O

Purity/Quality:

99.99%HPLC ^*data from raw suppliers

MK-6892 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of MK-6892

There total 2 articles about MK-6892 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

C20H24N4O5 → MK-6892 (917910-45-3)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

DOI:10.1021/jm100022r

Reference yield:

C28H32N4O6 (917911-03-6) → MK-6892 (917910-45-3)

Guidance literature:

C₂₈H₃₂N₄O₆; With chlorotriisopropylsilane; trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 0.25h;

With methanol; lithium hydroxide; water; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In water; pH=5;

upstream raw materials:

C₂₈H₃₂N₄O₆

Refernces

• 1、 -. "Niacin receptor agonists, compositions containing such compounds and methods of treatment". Page/Page column 29; 49. . Retrieved 2010/11/25.